Cognitive improvement following transvenous adipose-derived mesenchymal stem cell transplantation in a rat model of traumatic brain injury

被引：0
作者：
Dongfei Li
机构：
来源：
Neural Regeneration Research | 2011年 / 6卷 / 10期
基金：
中国国家自然科学基金;
关键词：
adipose-derived mesenchymal stem cells; traumatic brain injury; brain-derived nerve growth factor; cortex; stem cell transplantation; neural regeneration;
D O I：
暂无
中图分类号：
R651.15 [];
学科分类号：
1002 ; 100210 ;
摘要：
The effects of adipose-derived mesenchymal stem cell (ADMSC) transplantation for the repair of traumatic brain injury remain poorly understood. The present study observed neurological functional changes in a rat model of traumatic brain injury following ADMSC transplantation via the tail vein. Cell transplants were observed in injured cerebral cortex, and expression of brain-derived nerve growth factor was significantly increased in the injured hippocampus following transplantation. Results demonstrated that transvenous ADMSC transplants migrated to the injured cerebral cortex and significantly improved cognitive function.
引用
收藏
页码：732 / 737
页数：6
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