Th17细胞与自身免疫性疾病

被引：13
|
作者：
梁亮
王红
机构：
[1] 首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室
来源：
免疫学杂志 | 2010年 / 03期
基金：
北京市自然科学基金;
关键词：
Th17细胞; 自身免疫性疾病;
D O I：
10.13431/j.cnki.immunol.j.20100061
中图分类号：
R593.2 [自身免疫性疾病、结缔组织疾病];
学科分类号：
摘要：
Th17细胞是新近发现的一种新的CD4+T细胞亚群,其分化和增殖明显不同于Th1和Th2细胞,并且在多种自身免疫性疾病中发挥了重要的作用。通过对Th17细胞及其相关因子的研究,将会揭示这类疾病的发病机制,从而为治疗自身免疫性疾病提供新的途径。
引用
收藏
页码：264 / 266+270 +270
页数：4
相关论文
共 7 条
  • [1] Expression of Th17 cytokines in skin lesions of patients with psoriasis
    Li Jiawen
    Chen Xu'e
    Liu Zhixiang
    Yue Qing
    Liu Houjun
    [J]. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2007, 27 (03) : 330 - 332
  • [2] Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    Tzartos, John S.
    Friese, Manuel A.
    Craner, Matthew J.
    Palace, Jackie
    Newcombe, Jia
    Esiri, Margaret M.
    Fugger, Lars
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2008, 172 (01): : 146 - 155
  • [3] T cell-produced transforming growth factor-β1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
    Li, Ming O.
    Wan, Yisong Y.
    Flavell, Richard A.
    [J]. IMMUNITY, 2007, 26 (05) : 579 - 591
  • [4] TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    Veldhoen, M
    Hocking, RJ
    Atkins, CJ
    Locksley, RM
    Stockinger, B
    [J]. IMMUNITY, 2006, 24 (02) : 179 - 189
  • [5] The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivanov, Ivaylo I.
    McKenzie, Brent S.
    Zhou, Liang
    Tadokoro, Carlos E.
    Lepelley, Alice
    Lafaille, Juan J.
    Cua, Daniel J.
    Littman, Dan R.
    [J]. CELL, 2006, 126 (06) : 1121 - 1133
  • [6] IL-23is critical in theinduction but not in the effector phase of experimental autoim-mune encephalomyelitis .2 Thakker P,Leach MW,Kuang W,et al. J Immunol . 2007
  • [7] Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD .2 J Seiderer,I Elben,J Diegelmann,J Glas,J Stallhofer,C Tillack. Inflamm Bowel Dis . 2008
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