Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea

被引：0

作者：

Suk Pyo Shin ^{[1
,2
]}

Nam Keun Kim ^{[3
,4
]}

Ju Hwan Kim ^{[1
,2
]}

Ju Ho Lee ^{[1
,2
]}

Jung Oh Kim ^{[3
,4
]}

Sung Hwan Cho ^{[3
,4
]}

Hana Park ^{[1
,2
]}

Mi Na Kim ^{[5
]}

Kyu Sung Rim ^{[1
,2
]}

Seong Gyu Hwang ^{[1
,2
]}

机构：

[1] Department of Internal Medicine,CHA Bundang Medical Center,CHA University

[2] Institute of Gastroenterology,CHA Bundang Medical Center,CHA University

[3] Department of Biomedical Science,College of Life Science,CHA University

[4] Institute for Clinical Research,CHA Bundang Medical Center,CHA University 5. Department of Internal Medicine,CHA Gangnam Medical Center,CHA University

来源：

World Journal of Gastroenterology | 2015年 / 21卷 / 46期

基金：

新加坡国家研究基金会;

关键词：

Tumor necrosis factor-alpha; Polymorphism; Single nucleotide; Carcinoma; Hepatocellular;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

100214 ;

摘要：

AIM: To investigate associations between the tumor necrosis factor alpha(TNF-α)-1031 T>C,-863 C>A,-857 C>T,-308 G>A,and-238 G>A polymorphisms and HCC in Korea.METHODS: Hepatocellular carcinoma(HCC) cases were diagnosed at CHA Bundang Medical Center from June 1996 to August 2008. The association between TNF-α polymorphisms and HCC was analyzed in 157HCC patients and 201 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. We investigated five TNF-α polymorphisms,which are TNF-α-1031 T>C,-863 C>A,-857 C>T,-308 G>A,and-238 G>A. The TNF-α genotype frequencies,genotype combinations and haplotypes were analyzed to disclose the association with HCC.RESULTS: None of the TNF-α polymorphisms was significantly associated with HCC. However,nine genotype combinations had associations with increased likelihood of HCC. Among them,TNF-α-1031/-857/-238 TT/CC/GA(AOR = 18.849,95%CI: 2.203-161.246,P = 0.007),TNF-α-1031/-308/-238 TT/GG/GA(AOR = 26.956,95%CI: 3.071-236.584,P = 0.003),and TNF-α-1031/-238 TT/GA(AOR = 21.576,95%CI: 2.581-180.394,P = 0.005) showed marked association with HCC. There were five haplotypes of TNF-α polymorphisms which were significantly associated with HCC. They are TNF-α-1031/-863/-857/-308/-238 T-C-C-G-A(OR = 25.824,95%CI: 1.491-447.223,P = 0.0005),TNF-α-1031/-857/-308/-238 T-C-G-A(OR = 12.059,95%CI: 2.747-52.950,P < 0.0001),TNF-α-1031/-857/-238 T-C-A(OR = 10.696,95%CI: 2.428-47.110,P = 0.0001),TNF-α-1031/-308/-238 T-G-A(OR = 7.556,95%CI: 2.173-26.280,P = 0.0002) and TNF-α-1031/-238 T-A(OR = 10.865,95%CI: 2.473-47.740,P = 0.0001). Moreover,HCC Okuda stage Ⅲ cases with the TNF-α-1031 CC genotype had better survival than those with the TT genotype(AOR = 5.795,95%CI: 1.145-29.323). CONCLUSION: Although no single TNF-α polymorphism is associated with HCC in this study,some TNF-α genotype combinations and haplotypes are associated with HCC. In addition,HCC Okuda stage Ⅲ cases with the TNF-α-1031 TT genotype may have a better prognosis than those with the CC genotype.

引用

页码：13064 / 13072

页数：9

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