Alkaloids from an algicolous strain of Talaromyces sp.

被引：0

作者：

杨海滨 ^{[1
,2
]}

李昉 ^{[1
]}

季乃云 ^{[2
]}

机构：

[1] College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology

来源：

Journal of Oceanology and Limnology | 2016年 / 02期

基金：

中国国家自然科学基金;

关键词：

Talaromyces sp; alkaloid; chiral separation; quantum chemical calculation; bioactivity;

D O I：

暂无

中图分类号：

Q936 [微生物生物化学];

学科分类号：

071010 ;

摘要：

Compounds isolated and identified in a culture of the alga-endophytic fungus Talaromyces sp. cf-16 included two naturally occurring alkaloids, 2-[(S)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one( 1a) and 2-[(R)-hydroxy(phenyl)methyl]-3-methylquinazolin-4(3H)-one( 1b), that were identified for the first time. In addition, seven known compounds( 2 – 8) were obtained from the culture. Following chiral column chromatography, compounds 1a and 1b were identified as enantiomers by spectroscopic analyses and quantum chemical calculations. Bioassay results showed that 5 was more toxic to brine shrimp than the other compounds, and that 3 – 6 could inhibit Staphylococcus aureus.

引用

页码：367 / 371

页数：5

共 6 条

[1]

Determination of the Absolute Stereochemistry of Two New Aristophyllene Sesquiterpenes: A Combined Theoretical and Experimental Investigation[J] . Rui‐Bo Wu,Zhong‐Bin Cheng,Qing‐Hua Han,Ting‐Ting Lin,Jing‐Wei Zhou,Gui‐Hua Tang,Sheng Yin.Chirality . 2014 (4)

[2]

SpecDis: Quantifying the Comparison of Calculated and Experimental Electronic Circular Dichroism Spectra[J] . Torsten Bruhn,Anu Schauml?ffel,Yasmin Hemberger,Gerhard Bringmann.Chirality . 2013 (4)

[3]

Synthesis of 4,4′-biquinazoline alcohols as chiral catalysts in enantioselective alkynylation of aldehydes with phenyl acetylene[J] . Tetrahedron: Asymmetry . 2009 (24)

[4]

A new indoloditerpene derivative, penijanthine A, isolated from Penicillium janthinellum[J] . Takeshi Itabashi,Tomoo Hosoe,Daigo Wakana,Kazutaka Fukushima,Kayoko Takizawa,Takashi Yaguchi,Kaoru Okada,Galba Maria Campos Takaki,Ken-ichi Kawai.Journal of Natural Medicines . 2009 (1)

[5]

Determination of the absolute configurations of natural products via density functional theory calculations of vibrational circular dichroism, electronic circular dichroism, and optical rotation: The iso‐schizozygane alkaloids isoschizogaline and isoschizogamine[J] . Chirality . 2008 (3‐4)

[6]

Thomitrems A and E, two indole-alkaloid isoprenoids from Penicillium crustosum Thom[J] . Thomas Rundberget,Alistair L Wilkins.Phytochemistry . 2002 (8)

← 1 →