Simultaneous determination of borneol and its metabolite in rat plasma by GC-MS and its application to pharmacokinetic study

被引：1

作者：

Xiu-Man Sun ^{[1
]}

Qiong-Feng Liao ^{[1
]}

Yu-Ting Zhou ^{[2
]}

Xue-Jiao Deng ^{[2
]}

Zhi-Yong Xie ^{[2
]}

机构：

[1] School of Chinese Materia Medica,Guangzhou University of Chinese Medicine

[2] School of Pharmaceutical Sciences,Sun Yat-sen University

来源：

Journal of Pharmaceutical Analysis | 2014年 / 4卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Borneol; Camphor; Simultaneous determination; Pharmacokinetics; GC-MS;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

A gas chromatography mass spectrometry(GC-MS) method has been developed and fully validated for the simultaneous determination of natural borneol(NB) and its metabolite,camphor,in rat plasma.Following a single liquid-liquid extraction,the analytes were separated using an HP-5MS capillary column(0.25 mm × 30 m × 0.25 μm) and analyzed by MS in the selected ion monitoring mode.Selected ion monitor(m/z) of borneol,camphor and internal standard was 95,95 and 128,respectively.Linearity,accuracy,precision and extraction recovery of the analytes were all satisfactory.The method was successfully applied to pharmacokinetic studies of NB after oral administration to Wistar rats.

引用

页码：345 / 350

页数：6

共 50 条

[21] Simultaneous determination of evodiamine and its four metabolites in rat plasma by LC-MS/MS and its application to a pharmacokinetic study
Wang, Cuiyun
Yue, Fang
Ai, Guangfeng
Yang, Jie
BIOMEDICAL CHROMATOGRAPHY, 2018, 32 (07)
[22] Simultaneous Determination of Periplocymarin and its Metabolite in Rat Plasma by LC-MS/MS and their Application for Pharmacokinetics Study
Liu, Huaming
Li, Li
Wang, Meng
Azietaku, John T.
Ouyang, Huizi
He, Jun
LATIN AMERICAN JOURNAL OF PHARMACY, 2018, 37 (03): : 529 - 534
[23] Simultaneous determination of dextromethorphan and dextrophan in rat plasma by LC-MS/MS and its application to a pharmacokinetic study
Xu, Renai
Xu, Tao
Wang, Zhe
Zhan, Haichao
Chen, Xiaole
Wang, Xianqin
Hu, Lufeng
Zhang, Xiuhua
PHARMAZIE, 2012, 67 (06): : 485 - 489
[24] Simultaneous Determination of Luteolin and Ayanin in Rat Plasma by HPLC-MS-MS and its Application in a Pharmacokinetic Study
Li, Li
Liang, Ji-Jun
Liu, Yu
Chen, Li-Jiang
Zhang, Wen-Jun
Lu, En
LATIN AMERICAN JOURNAL OF PHARMACY, 2014, 33 (09): : 1475 - 1480
[25] Simultaneous determination of meropenem and imipenem in rat plasma by LC-MS/MS and its application to a pharmacokinetic study
Peng, Li
Wang, Xinyu
Dang, Hongwan
BIOMEDICAL CHROMATOGRAPHY, 2021, 35 (11)
[26] Simultaneous determination of mangiferin and neomangiferin in rat plasma by UPLC-MS/MS and its application for pharmacokinetic study
Qiu, Xiangjun
Zhao, Jian-long
Hao, Cong
Yuan, Canli
Tian, Nuan
Xu, Zhi-sheng
Zou, Ruan-min
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 124 : 138 - 142
[27] Simultaneous determination of entecavir and lamivudine in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study
Jiang, Qikun
Liu, Yan
Wang, Yunjie
Sun, Yinghua
Li, Bo
Li, Zhenbao
Lu, Tianshu
Wang, Shang
He, Zhonggui
RSC ADVANCES, 2016, 6 (75): : 70990 - 70998
[28] Simultaneous determination of ipratropium and salbutamol in rat plasma by LC-MS/MS and its application to a pharmacokinetic study
Wu, Jingwen
Ding, Cungang
Ge, Qinghua
Li, Zhou
Zhou, Zhen
Zhi, Xiaojin
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2011, 879 (30): : 3475 - 3483
[29] Simultaneous Determination of Rivaroxaban and Enalapril in Rat Plasma by UPLC–MS/MS and Its Application to A Pharmacokinetic Interaction Study
Shu Zheng
Shun-Bin Luo
Yi-Bin Mei
Jing Guo
Li-Jun Tong
Qiang Zhang
Xia-Yan Ye
European Journal of Drug Metabolism and Pharmacokinetics, 2019, 44 : 229 - 236
[30] Simultaneous determination of doxorubicin and curcumin in rat plasma by LC-MS/MS and its application to pharmacokinetic study
Ma, Wenzhuan
Wang, Jinling
Gun, Qiang
Tu, Pengfei
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2015, 111 : 215 - 221

← 1 2 3 4 5 →