Neuroglobin expression in rats after traumatic brain injury

被引：0
作者：
Xin LinMin LiAijia ShangYazhuo HuXiao YangLing YeSuyan BianZhongfeng WangDingbiao Zhou Department of SurgeryDivision of NanlouGeneral Hospital of Chinese PLABeijing China Department of TraumaticAesthetic SurgeryHuangsi Aesthetic Surgery HospitalBeijing China Department of NeurosurgeryDivision of SurgeryGeneral Hospital of Chinese PLABeijing China Institute of GeriatricsGeneral Hospital of Chinese PLABeijing China Institute of Microbiology and EpidemiologyAcademy of Military Medical SciencesBeijing China Department of CardiologyDivision of NanlouGeneral Hospital of Chinese PLABeijing China Institute of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai China [1 ,2 ,3 ,4 ,5 ,4 ,6 ,7 ,3 ,1 ,100853 ,2 ,100120 ,3 ,100853 ,4 ,100853 ,5 ,100071 ,6 ,100853 ,7 ,200032 ]
机构：
来源：
NeuralRegenerationResearch | 2012年 / 7卷 / 25期
关键词：
neuroglobin; traumatic brain injury; neuron; apoptosis; cerebral cortex; Bax; Bcl-2; neural regenera-tion;
D O I：
暂无
中图分类号：
R651.1 [颅脑];
学科分类号：
1002 ; 100210 ;
摘要：
In this study,we used a rat model of severe closed traumatic brain injury to explore the relationship between neuroglobin,brain injury and neuronal apoptosis.Real-time PCR showed that neuroglobin mRNA expression rapidly increased in the rat cerebral cortex,and peaked at 30 minutes and 48 hours following traumatic brain injury.Immunohistochemical staining demonstrated that neu-roglobin expression increased and remained high 2 hours to 5 days following injury.The rate of in-crease in the apoptosis-related Bax/Bcl-2 ratio greatly decreased between 30 minutes and 1 hour as well as between 48 and 72 hours post injury.Expression of neuroglobin and the anti-apoptotic factor Bcl-2 greatly increased,while that of the proapoptotic factor decreased,in the cerebral cortex post severe closed traumatic brain injury.It suggests that neuroglobin might protect neurons from apoptosis after traumatic injury by regulating Bax/Bcl-2 pathway.
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页码：1960 / 1966
页数：7
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