DNA Methylation and Birth Weight: a Genome-wide Analysis

被引：0

作者：

MAO Li Li ^{[1
,2
]}

XIAO Xin Hua ^{[1
]}

ZHANG Qian ^{[1
]}

ZHENG Jia ^{[1
]}

LI Wen Hui ^{[1
]}

YU Miao ^{[1
]}

ZHANG Hua Bing ^{[1
]}

PING Fan ^{[1
]}

XU Jian Ping ^{[1
]}

WANG Xiao Jing ^{[1
]}

机构：

[1] Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College

[2] Department of Endocrinology, Civil Aviation General Hospital

来源：

BiomedicalandEnvironmentalSciences | 2017年 / 30卷 / 09期

关键词：

DNA Methylation and Birth Weight; ASP; LBW; DNAmethylation;

D O I：

暂无

中图分类号：

R722.1 [新生儿疾病];

学科分类号：

100202 ;

摘要：

The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite‐converted DNA. We have identified many differentially methylated Cp G sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin‐signaling pathway(ISP), adipocytokine signaling pathway(ASP) and MAPK signaling pathway are involved in the fetal programming of diabetes.

引用

页码：667 / 670

页数：4

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