Correlation of Lower Concentrations of Hydrogen Sulfide with Activation of Protein Kinase CβII in Uremic Accelerated Atherosclerosis Patients

Background: Hydrogen sulfide (H2S) plays a protective role in chronic hemodialysis (CHD) patients. In this study, we further investigate the relationship between H2S and conventional protein kinase CβII (cPKCβII) in CHD patients with uremic accelerated atherosclerosis (UAAS).Methods: A total of 30 healthy people, 30 CHD patients without AS and 30 CHD patients with AS (CHD + AS) were studied. Plasma H2S was measured with a sulfide sensitive electrode, and cPKCβII membrane translocation was detected by Western blotting.Results: Plasma H2S in CHD + AS group was significantly lower than that in CHD patients. cPKCβII membrane translocation in CHD + AS group increased significantly compared with CHD group. Plasma H2S concentration was negatively correlated with cPKCβII membrane translocation in CHD + AS patients.Conclusions: These findings suggest a possible linkage between H2S metabolism and cPKCβII activation, which may contribute to the development of UAAS in CHD patients.