Synthesis,antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides

被引：2

作者：

Davinder Kumar ^{[1
]}

Archana Kapoor ^{[1
]}

Ananda Thangadurai ^{[2
]}

Pradeep Kumar ^{[3
]}

Balasubramanian Narasimhan ^{[3
]}

机构：

[1] Department of Pharmaceutical Sciences Guru Jambheshwar University of Science and Technology,Hisar ,India

[2] Department of Pharmaceutical Chemistry Swamy Vivekanandha College of Pharmacy,Tiruchengode ,India

[3] Faculty of Pharmaceutical Sciences Maharshi Dayanand University,Rohtak ,India

来源：

Chinese Chemical Letters | 2011年 / 22卷 / 11期

关键词：

Benzylidene hydrazides; Synthesis; Antimicrobial; mt-QSAR; LOO method;

D O I：

暂无

中图分类号：

TQ460.1 [基础理论];

学科分类号：

1007 ;

摘要：

<正>A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides（1-20） was synthesized and tested for in vitro antimicrobial activity.The results of antimicrobial studies indicated that the compounds having dinitro,methoxy,hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones.The QSAR investigation indicated the importance of the topological parameter,third order molecular connectivity index（3x） in describing the antimicrobial activity of synthesized hydrazides.

引用

页码：1293 / 1296

页数：4

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