Atherosclerosis and the role of immune cells

被引：0

作者：

Fulya Ilhan ^{[1
]}

Sevgi Tas Kalkanli ^{[2
]}

机构：

[1] Department of Immunology, Faculty of Medicine, University of Firat

[2] Department of Immunology, Faculty of Medicine, University of Dicle

来源：

World Journal of Clinical Cases | 2015年 / 04期

关键词：

Atherosclerosis; Inflammatory cytokines; Pro-inflammatory mediators; Immune cells; Adhesion molecules;

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon(IFN)-α and β are generated upon the activation of tolllike receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-γ and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immunecells in the atherosclerosis.

引用

页码：345 / 352

页数：8

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