抑郁症患者血清细胞因子水平的研究

被引：46

作者：

杨权

林凌云

李景吾

许崇涛

邓质波

机构：

[1] 汕头大学医学院精神卫生中心

[2] 汕头大学医学院附属第一医院内科

来源：

中华精神科杂志 | 2001年 / 01期

关键词：

抑郁症; 白细胞介素类; 肿瘤坏死因子; 干扰素Ⅱ型;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100205 ;

摘要：

目的　探讨细胞因子在抑郁症发病中的作用。方法　用酶联免疫吸附法检测 2 2例抑郁症患者 (抑郁症组 )和 2 0名正常人 (对照组 )的血清白细胞介素 (IL) 1 β、IL 2、IL 6、肿瘤坏死因子 α(TNF α)和γ 干扰素 (IFN γ)水平 ,均以nmol/L计。结果　抑郁症组血清IL 2水平为 0 46± 0 5 2 ,明显高于对照组的 0 15± 0 19(t=2 5 17,P <0 0 5 )。抑郁症组的IL 1β、IL 6、TNF α和IFN γ水平分别为0 32± 0 5 7,0 14± 0 37,0 0 3± 0 0 5和 0 0 5± 0 13,与对照组 (分别为 0 2 3± 0 2 5 ,0 0 8± 0 2 3,0 0 5±0 0 9和 0 0 1± 0 0 4)比较 ,差异无显著性 (t分别为 0 6 45 ,0 5 89,1 0 99和 1 110 ,P >0 0 5 )。结论　抑郁症患者的血清IL 2水平升高 ,提示IL 2可能在抑郁症的发病中起一定作用

引用

页码：16 / 17

页数：2

共 10 条

[1]

Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression. Maes M,Meltzer HY,Bosmans E,et al. Journal of Affective Disorders . 1995

[2]

The influence of interleukin-2 on vasopressin and oxytocin gene expression in the rodent hypothalamus. Pardy K,Murphy D,Carter D,et al. J Neuroimmunol . 1993

[3]

Interleukin-2 induces corticotropin-releasing hormone release from superfused rat hypothalami: influence of glucocorticoids. Cambronero JC,Rivas FJ,Borrell J,et al. The Journal of Endocrinology . 1992

[4]

Blood levels of cytokines in elderly patients with major depressive disorder. Brambilla F,Maggioni M. Acta Psychiatrica Scandinavica . 1998

[5]

The macrophage theory of depression. Smith RS. Medical Hypotheses . 1991

[6]

The monocyte-T-lymphocyte hypothesis of major depression. Maes M,Smith R,Scharpe S. Psychoneuroendocrinology . 1995

[7]

Interleukin-1beta: a putative mediator of HPA axis hyperactivity in major depression. Maes M,Bosmans E,Meltzer HY,et al. American Journal of Psychiatry . 1993

[8]

IL-2 induces vasopressin release from the hypothalamus and the amygdala: role of nitric oxide-mediated signaling. Raber J,Bloom FE. The Journal of Neuroscience . 1994

[9]

Indicators of immune activation in major depression. Sluzewska A,Rybakowski J,Bosmans E,etal. Psychiatry Research . 1996

[10]

Inflammatory cytokines within the central nerveous system: sources, function, and mechanism of action. Benveniste EN. American Journal of Physiology . 1992

← 1 →