IL-21/IL-21R信号在IBD病变形成机制中作用的研究进展

被引：2

作者：

姜雪峰 ^{[1
]}

贾楠 ^{[1
]}

牛译晨 ^{[1
,2
]}

岳丹 ^{[1
,3
]}

王媛媛 ^{[4
]}

张晓清 ^{[1
]}

孙逊 ^{[1
]}

机构：

[1] 中国医科大学基础医学院免疫学教研室

[2] 中国医科大学第一临床学院

[3] 中国医科大学附属盛京医院检验科

[4] 中国医科大学附属第四医院麻醉科

来源：

微生物学杂志 | 2018年 / 38卷 / 06期

关键词：

炎症性肠病; IL-21/IL-21R信号; 辅助性T细胞;

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

摘要：

炎症性肠病(Inflammatory bowel disease,IBD)的发病机制至今尚不明确,普遍认为是由肠黏膜免疫调节异常、持续性肠道感染、肠黏膜屏障缺损、遗传和环境等多种因素相互作用导致的。近年来,研究发现IBD患者血清中IL-21水平异常升高,提示IL-21/IL-21R信号可能在IBD的病变形成中发挥重要作用。IL-21是一种重要的具有多重生物学功能的细胞因子,通过对CD4+T细胞、CD8+T细胞、Th17细胞、B细胞、巨噬细胞、树突状细胞等多种细胞产生影响,从而参与IBD的发生发展。本文就IL-21/IL-21R信号在炎症性肠病发病机制中的研究进展进行综述。

引用

页码：103 / 106

页数：4

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