超重及肥胖者血清TNF-α、IL-6、CRP水平变化及意义的研究

被引：9

作者：

罗勇 ^{[1
]}

李小平 ^{[1
]}

吕湛 ^{[1
]}

陈丽 ^{[1
]}

覃数 ^{[2
]}

机构：

[1] 川北医学院附属医院心内科

[2] 重庆医科大学附属第一医院

来源：

四川医学 | 2008年 / 06期

关键词：

超重及肥胖; 肿瘤坏死因子-α; 白细胞介素-6; C反应蛋白;

D O I：

10.16252/j.cnki.issn1004-0501-2008.06.016

中图分类号：

R589.2 [脂肪代谢障碍];

学科分类号：

摘要：

目的探讨在超重及肥胖患者中血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平变化及意义。方法58例体重正常者和24例超重及肥胖者常规测量血压、体重、身高、腰围、臀围,计算体重指数(BMI)、腰臀比(WHR)。抽取空腹静脉血检测其IL-6、CRP、TNF-α的水平。结果在超重及肥胖者中,BMI、WHR、收缩压、餐后2h血糖、三酰甘油、空腹胰岛素、IL-6水平[(21.16±10.85 VS 15.79±3.45)μg/ml,P=0.023]、CRP水平[(3.77±10.4 VS 1.70±0.65)mg/L,P=0.036]均高于正常体重组,而舒张压、TNF-α[(49.99±35.61 VS 38.30±20.70)ng/ml,P=0.074]的水平在两组间无统计学意义。在超重及肥胖患者中,IL-6、CRP、TNF-α与肥胖相关指数(BMI、WHR)正相关(P<0.05);IL-6、CRP分别与餐后2h血糖和空腹胰岛素水平正相关(P<0.05和P<0.01)。结论在超重及肥胖人群中存在着部分炎症指标的异常,提示超重及肥胖与炎症密切相关。

引用

页码：658 / 660

页数：3

共 14 条

[1] Relation between cytokines（TNF-α,IL-1 and 6）and homocysteine in android obesity and the phe-nomenonof insulin resistance syndromes. Hrnciar J,Gabor D,Hrnciarova M,et al. Vnitrni Lekarstvi . 1999
[2] Role of Adipokines in the Obesity–Inflammation Relationship: The Effect of Fat Removal[J] . Katherine Esposito,Giovanni Giugliano,Nicolò Scuderi,Dario Giugliano. &nbspPlastic and Reconstructive Surgery . 2006 (4)
[3] Is Type II diabetes mellitus a disease of the innate immune system?
Pickup, JC
Crook, MA
[J]. DIABETOLOGIA, 1998, 41 (10) : 1241 - 1248
[4] The association of leucocyte count,fi-broinogen and C-reactive protein withvascular riskfactorsandischemicvas-cular diseases. Gran AJ,Buggle F,Becher H,et al. Thrombosis Research . 1996
[5] Involvement of the hemo-staticsystemintheinsulinresistancesyndrome:astudy of 1500 patientswithangi-na pectoris:the ECTA Angina Pectoris Study Group. Juhan Vague I,Thompson SG,Jespersen J. Arteriosclerosis and Thrombosis . 1993
[6] The association of leukocyte count, fibrinogen and c-reactive protein with vascular risk factors and ischemic vascular diseases[J] . Armin J Grau,Florian Buggle,Heiko Becher,Egon Werle,Werner Hacke. &nbspThrombosis Research . 1996 (3)
[7] C Reactive Protein And Its Relation To Cardiovascular Risk Factors: A Population Based Cross Sectional Study[J] . M. A. Mendall,Praful Patel,Lydia Ballam,D. Strachan,T. C. Northfield. &nbspBMJ: British Medical Journal . 1996 (7038)
[8] Role of adipokines in the obesity-inflammation relationship:the effect of fat removal. Esposito K,Giugliano G,Scuderi N,et al. Plastic and Reconstructive Surgery . 2006
[9] Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Uysal KT,Wiesbrack SM,Marino MW, et al. Nature . 1997
[10] C-reactive protein andits relationtocardiovascular risk factors:a population based cross section study. Mendall MA,Patel P,BallamL,et al. British Medical Journal . 1996

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