Effect and mechanism of homocysteine on Parkinson's disease induced by 6-OHDA

被引：0

作者：

Hongxia Xing a

机构：

来源：

The Journal of Biomedical Research | 2008年 / 01期

关键词：

Parkinson’s disease; 6-hydroxydopamine; homocysteine; tyrosine hydroxylase;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

1002 ;

摘要：

Objective:To study the effects and mechanism of homocysteine(Hcy)on Parkinson’s disease(PD)induced by 6-hydroxydopamine(6-OHDA)in vivo.Methods:Forty rats were divided into 4 groups.6-OHDA or the solvent of 6-OHDA was focally administrated to induce PD,2 h later Hcy or 0.9% sodium chloride was administrated in the ipsolateral substantial nigra(SN).We used behavioral testing,Immolunohistochemical techniques,biochemistry techniques to detect the injury of SN.Results:The rotary turns of PD rats induced by 6-OHDA showed significant increase after treatment with Hcy compared with the controls(P < 0.05).Also the numbers of tyrosine hydroxylase(TH)-stained neurons were decreased,and dendrites were fragmented and truncated.Free radicals were increased and antioxidant enzymes decreased.Conclusion:Focal infusion of Hcy into the SN increased the vulnerability of the dopaminergic neurons to 6-OHDA-induced degeneration,it seems that the endangering effect of Hcy is due to exacerbating oxidative stress.

引用

页码：12 / 17

页数：6

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