Antioxidation Activities of Low-Molecular-Weight Gelatin Hydrolysate Isolated from the Sea Cucumber Stichopus japonicus

被引：0
|
作者：
WANG Jingfeng
机构：
来源：
Journal of Ocean University of China | 2010年 / 9卷 / 01期
基金：
中国国家自然科学基金;
关键词：
sea cucumber; low-molecular-weight gelatin hydrolysate; antioxidation activity; antimelanogenesis; tyrosinase; reduced glutathione;
D O I：
暂无
中图分类号：
R285 [中药药理学];
学科分类号：
摘要：
Gelatin extracted from the body wall of the sea cucumber (Stichopus japonicus) was hydrolyzed with flavourzyme.Low-molecular-weight gelatin hydrolysate (LMW-GH) of 700-1700 Da was produced using an ultrafiltration membrane bioreactor system.Chemiluminescence analysis revealed that LMW-GH scavenges high free radicals in a concentration-dependent manner;IC50 value for superoxide and hydroxyl radicals was 442 and 285 μg mL-1,respectively.LMW-GH exhibited excellent inhibitory characteristics against melanin synthesis and tyrosinase activity in B16 cells.Furthermore,LMW-GH notably increased intracellular glutathione (GSH),which in turn suppressed melanogenesis.LMW-GH performs antioxidation activity,holding the potential of being used as a valuable ingredient in function foods,cosmetics and pharmaceuticals or nutriceuticals.
引用
收藏
页码：94 / 98
页数：5
相关论文
共 50 条
  • [41] Study of a highly alkaline protease extracted from digestive tract of sea cucumber (Stichopus japonicus)
    Fu, XY
    Xue, CH
    Miao, BC
    Li, ZJ
    Yang, WG
    Wang, DF
    FOOD RESEARCH INTERNATIONAL, 2005, 38 (03) : 323 - 329
  • [42] Identification of antioxidative oligopeptides derived from autolysis hydrolysates of sea cucumber (Stichopus japonicus) guts
    Zheng, Jie
    Wu, Hai-Tao
    Zhu, Bei-Wei
    Dong, Xiu-Ping
    Zhang, Mao-Mao
    Li, Yue-Ling
    EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 2012, 234 (05) : 895 - 904
  • [43] Purification and characterization of a cysteine-like protease from the body wall of the sea cucumber Stichopus japonicus
    Qi, H.
    Dong, X. P.
    Cong, L. N.
    Gao, Y.
    Liu, L.
    Mikiro, T.
    Zhu, B. W.
    FISH PHYSIOLOGY AND BIOCHEMISTRY, 2007, 33 (02) : 181 - 188
  • [44] Morphological transformation and proliferation of rat astrocytes as induced by sulfated polysaccharides from the sea cucumber Stichopus japonicus
    Sheng, Xiehuang
    Zhang, Nannan
    Song, Shuliang
    Li, Min
    Liang, Hao
    Zhang, Yuejie
    Wang, Yunshan
    Ji, Aiguo
    NEUROSCIENCE LETTERS, 2011, 503 (01) : 37 - 42
  • [45] Effects of sulfated fucan from the sea cucumber Stichopus japonicus on natural killer cell activation and cytotoxicity
    Surayot, Utoomporn
    Lee, SangMin
    You, SangGuan
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 108 : 177 - 184
  • [46] Identification of novel oligopeptides from the simulated digestion of sea cucumber (Stichopus japonicus) to alleviate Aβ aggregation progression
    Lin, Xiaoling
    Yao, Maojin
    Lu, Jia-Hong
    Wang, Yi
    Yin, Xiquan
    Liang, Ming
    Yuan, Erdong
    Ren, Jiaoyan
    JOURNAL OF FUNCTIONAL FOODS, 2019, 60
  • [47] Effects of N-terminal deletion mutation on arginine kinase from the sea cucumber Stichopus japonicus
    Liu, Tao-Tao
    Wang, Xi-Cheng
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2008, 42 (01) : 68 - 74
  • [48] Purification and characterization of a cysteine-like protease from the body wall of the sea cucumber Stichopus japonicus
    H. Qi
    X. P. Dong
    L. N. Cong
    Y. Gao
    L. Liu
    T. Mikiro
    B. W. Zhu
    Fish Physiology and Biochemistry, 2007, 33 : 181 - 188
  • [49] Identification and characterization of microsatellite markers derived from expressed sequence tags of the sea cucumber Stichopus japonicus
    Chen, Limei
    Li, Qi
    MOLECULAR ECOLOGY NOTES, 2007, 7 (06): : 1057 - 1059
  • [50] Characterization of proteases from the digestive tract of sea cucumber (Stichopus japonicus):: High alkaline protease activity
    Fu, XY
    Xue, CH
    Miao, BC
    Li, ZJ
    Gao, X
    Yang, WG
    AQUACULTURE, 2005, 246 (1-4) : 321 - 329
12345