Antioxidation Activities of Low-Molecular-Weight Gelatin Hydrolysate Isolated from the Sea Cucumber Stichopus japonicus

被引：0
|
作者：
WANG Jingfeng
机构：
来源：
Journal of Ocean University of China | 2010年 / 9卷 / 01期
基金：
中国国家自然科学基金;
关键词：
sea cucumber; low-molecular-weight gelatin hydrolysate; antioxidation activity; antimelanogenesis; tyrosinase; reduced glutathione;
D O I：
暂无
中图分类号：
R285 [中药药理学];
学科分类号：
摘要：
Gelatin extracted from the body wall of the sea cucumber (Stichopus japonicus) was hydrolyzed with flavourzyme.Low-molecular-weight gelatin hydrolysate (LMW-GH) of 700-1700 Da was produced using an ultrafiltration membrane bioreactor system.Chemiluminescence analysis revealed that LMW-GH scavenges high free radicals in a concentration-dependent manner;IC50 value for superoxide and hydroxyl radicals was 442 and 285 μg mL-1,respectively.LMW-GH exhibited excellent inhibitory characteristics against melanin synthesis and tyrosinase activity in B16 cells.Furthermore,LMW-GH notably increased intracellular glutathione (GSH),which in turn suppressed melanogenesis.LMW-GH performs antioxidation activity,holding the potential of being used as a valuable ingredient in function foods,cosmetics and pharmaceuticals or nutriceuticals.
引用
收藏
页码：94 / 98
页数：5
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