脱泛素酶OTUD7B调控肿瘤微环境和肿瘤进程的分子机制

被引：1

作者：

林丹丹 ^{[1
]}

申阳 ^{[1
]}

解欣 ^{[1
,2
]}

史建红 ^{[1
]}

机构：

[1] 河北大学附属医院实验中心,河北省肿瘤放化疗机制与规程研究重点实验室

[2] 河北大学医学院

来源：

中国病理生理杂志 | 2019年 / 35卷 / 09期

关键词：

脱泛素酶; 信号转导; 泛素化; 肿瘤微环境;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

摘要：

<正>泛素化（ubiquitination）是一种蛋白质翻译后修饰过程,泛素（ubiquitin）以共价连接的方式形成多聚泛素链并结合到靶蛋白赖氨酸（lysine,K）残基上,该过程由泛素激活酶（ubiquitin-activating enzymes,UBE,E1）、泛素结合酶（ubiquitin-conjugating enzymes,UCE,E2）和泛素连接酶（ubiquitin ligases,E3）顺序激活[1]。经典的泛素化调节方

引用

页码：1710 / 1715

页数：6

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