The association of N-terminal pro-B-type natriuretic peptide level with short-term mortality in elderly patients with sepsis

Background Sepsis is a dysregulated host response to an infection with high prevalence and mortality in elderly population. The predictive value of N-terminal pro-B-type natriuretic peptide(NT-pro BNP) in elderly septic patients is yet unknown. Method Elderly patients(≥60 years old) with sepsis, that admitted to the Guangzhou Panyu Central Hospital from January 2019 to December 2021 were consecutively recruited. All patients were followed up for 28 days since admission and the event of death was recorded. The Cox regression analysis and receiver operation characteristic(ROC) analysis were performed to study the association between NT-pro BNP and mortality. Results A total of 490 patients were included, and divided into: survival group(n=304, 62.0%)and death group(n=186, 38.0%). The multivariate Cox regression analysis showed that higher lg(NT-pro BNP)(HR=1.60, 95% CI 1.24-2.06, P<0.001, Table 2), liver disease(HR=5.22, 95% CI 2.26-12.03, P<0.001, Table 2),higher serum lactic acid(HR=1.09, 95% CI 1.05-1.14, P<0.001, Table 2) were independently associated with28-day mortality in sepsis. ROC analysis for NT-pro BNP in predicting 28-day mortality demonstrated an AUC of0.663(95%CI 0.614-0.712), with NT-pro BNP=7233 pg/ml as the optimal cut-off value. The sensitivity was 50.5%and the specificity was 73.7%. Conclusion NT-pro BNP could be a feasible predictor for mortality in elderly patients with sepsis.[S Chin J Cardiol 2022;23(4):247-253]