Effects of genistein on neuronal apoptosis,and expression of Bcl-2 and Bax proteins in the hippocampus of ovariectomized rats

被引：4

作者：

Yun Peng ^{[1
]}

Bo Jiang ^{[1
]}

Huiling Wu ^{[1
]}

Ruchun Dai ^{[2
]}

Liming Tan ^{[1
]}

机构：

[1] Department of Neurology,the Second Xiangya Hospital,Central South University

[2] Institute of Endocrinology and Metabolism,the Second Xiangya Hospital,Central South University

来源：

NeuralRegenerationResearch | 2012年 / 7卷 / 36期

关键词：

ovariectomized model; rats; hippocampus; apoptosis; Bcl-2; Bax; genistein; 17β-estradiol; brain injury; neural regeneration;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

Genistein is one of several isoflavones that has a structure similar to 17β-estradiol, has a strong antioxidant effect, and a high affinity to estrogen receptors. At 15 weeks after ovariectomy, the expression of Bcl-2 in the hippocampus of rats decreased and Bax expression increased, with an obvious upregulation of apoptosis. However, intraperitoneal injection of genistein or 17β-estradiol for 15 consecutive weeks from the second day after operation upregulated Bcl-2 protein expression downregulated Bax protein expression, and attenuated hippocampal neuron apoptosis. Our experimental findings indicate that long-term intervention with genistein can lead to a decrease in apoptosis in hippocampal neurons following ovariectomy, upregulate the expression of Bcl-2, and downregulate the expression of Bax. In addition, genistein and 17β-estradiol play equal anti-apoptotic and neuroprotective roles.

引用

页码：2874 / 2881

页数：8

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