Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice

被引：0

作者：

Chen Wang ^{[1
,2
,3
]}

Junying Bai ^{[2
,3
]}

Botao Wang ^{[2
,4
]}

Leilei Yu ^{[2
,3
]}

Fengwei Tian ^{[2
,3
,5
]}

Jianxin Zhao ^{[2
,3
]}

Hao Zhang ^{[2
,3
,5
,6
]}

Huayi Suo ^{[1
]}

Wei Chen ^{[2
,3
,5
]}

Qixiao Zhai ^{[2
,3
]}

机构：

[1] College of Food Science, Southwest University

[2] State Key Laboratory of Food Science and Technology, Jiangnan University

[3] School of Food Science and Technology, Jiangnan University

[4] Bloomage Biotechnology Co., Ltd.

[5] National Engineering Research Center for Functional Food, Jiangnan University

[6] Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch

来源：

Food Science and Human Wellness | 2023年 / 12卷 / 06期

关键词：

D O I：

暂无

中图分类号：

TS201.4 [食品营养学];

学科分类号：

083201 ;

摘要：

Stachyose is a prebiotic that traditionally extracted from plants, such as vegetable. It has been demonstrated to alleviate intestinal inflammation by regulating gut microbiota, but the mechanism has been unclear. This research aims to detect the potential mechanism of stachyose in alleviating the severity of ulcerative colitis(UC). The results indicated that the administration of stachyose could recover the body weight, protect against the colonic tissue damage, reduce the pro-inflammatory cytokines levels, and reverse the histological abnormalities in UC mice. Oral stachyose could restore dextran sulfate sodium(DSS)-induced disturbance in intestinal bacteria. Besides, the metabolome result of serum samples showed that stachyose treatment significantly altered serum metabolites against inflammatory responses in colitis mice. Also, a significant correlation can be found between 23 metabolite biomarkers and 18 differential genera. Our results provided a strong foundation for the future study of the protective role of stachyose in maintaining intestinal homeostasis.

引用

页码：2211 / 2220

页数：10

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