Design,synthesis and in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antitubercular and antimalarial agents

被引：2

作者：

Tarunkumar Naniibhai Akhaia ^{[1
]}

Jignesh Privakant Raval ^{[1
]}

机构：

[1] Department of Pharmaceutical Chemistry,Ashok & Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences(ARIBAS),New Vallabh Vidyanagar 388121,India

来源：

ChineseChemicalLetters | 2012年 / 23卷 / 07期

关键词：

Tetrahydropyrimidines-isatin hybrid; Biginelli reaction; In vitro antitubercular; Antimalarial activity;

D O I：

暂无

中图分类号：

O621.2 [有机化合物性质];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 5-substituted-3-[{5-(6-methyl-2-oxo/thioxo-4-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl}-imino] -1,3-dihydro-2H-indol-2-one were synthesized,characterized and screened for their anti-tubercular and antimalarial activity.

引用

页码：785 / 788

页数：4

共 50 条

[21] Synthesis, pharmacological evaluation, and molecular modeling studies of novel isatin hybrids as potential anticancer agents
Raju, Rajapandi
Chidambaram, Kumarappan
Chandrasekaran, Balakumar
Maity, Tapan Kumar
Alkahtani, Abdullah M.
Chandramoorthy, Harish C.
Bayan, Mohammad F.
JOURNAL OF SAUDI CHEMICAL SOCIETY, 2023, 27 (02)
[22] SYNTHESIS, PHARMACOLOGICAL EVALUATION, AND MOLECULAR MODELING STUDIES OF NEW ISATIN HYBRIDS AS POTENTIAL ANTICANCER AGENTS
Raju, Rajapandi
Chidambaram, Kumarappan
Chandrasekaran, Balakumar
Maity, Tapan Kumar
PHARMACEUTICAL CHEMISTRY JOURNAL, 2023, 56 (10) : 1389 - 1399
[23] Design, synthesis and evaluation of novel carboline-triazole hybrids as promising antimalarial agents
Kushawaha, Ajay Kishor
Nandi, Rohini
Jaiswal, Arvind Kumar
Bhatt, Hemlata
Katiyar, Sarita
Ansari, Alisha
Choudhury, Abhijit Deb
Ali, Shabeer
Mishra, Shikha
Bhatta, Rabi Sankar
Srivastava, Mrigank
Mishra, Satish
Sashidhara, Koneni, V
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 290
[24] Pyridazinone hybrids: Design, synthesis and evaluation as potential anticonvulsant agents
Partap, Sangh
Akhtar, Md. Jawaid
Yar, Mohammed Shahar
Hassan, Mohd. Zaheen
Siddiqui, Anees Ahmad
BIOORGANIC CHEMISTRY, 2018, 77 : 74 - 83
[25] Design, synthesis, and biological evaluation of β-ketosulfonamide adenylation inhibitors as potential antitubercular agents
Vannada, Jagadeshwar
Bennett, Eric M.
Wilson, Daniel J.
Boshoff, Helena I.
Barry, Clifton E., III
Aldrich, Courtney C.
ORGANIC LETTERS, 2006, 8 (21) : 4707 - 4710
[26] New Potential Antimalarial Agents: Design, Synthesis and Biological Evaluation of Some Novel Quinoline Derivatives as Antimalarial Agents
Radini, Ibrahim Ali M.
Elsheikh, Tarek M. Y.
El-Telbani, Emad M.
Khidre, Rizk E.
MOLECULES, 2016, 21 (07):
[27] Synthesis and in vitro evaluation of novel 8-aminoquinoline-pyrazolopyrimidine hybrids as potent antimalarial agents
Murugan, Kannan
Raichurkar, Anandkumar V.
Khan, Fazlur Rahman Nawaz
Iyer, Pravin S.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (05) : 1100 - 1103
[28] Design, Synthesis and Antiplasmodial Evaluation of Sulfoximine-triazole Hybrids as Potential Antimalarial Prototypes
Mabasa, Tommy F.
Awe, Babatunde
Laming, Dustin
Kinfe, Henok H.
MEDICINAL CHEMISTRY, 2019, 15 (06) : 685 - 692
[29] Antimalarial and antitubercular nostocarboline and eudistomin derivatives: Synthesis, in vitro and in vivo biological evaluation
Bonazzi, Simone
Barbaras, Damien
Patiny, Luc
Scopelliti, Rosario
Schneider, Patricia
Cole, Stewart T.
Kaiser, Marcel
Brun, Reto
Gademann, Karl
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (04) : 1464 - 1476
[30] Design, synthesis, and in vitro cytotoxicity evaluation of novel dihydroartemisinin-isatin hybrids tethered via different length of esters as potential anti-breast cancer agents
Xu, Zhi
Pan, Bowen
Chen, Linzhi
Xu, Dan
FITOTERAPIA, 2023, 166

← 1 2 3 4 5 →