Relaxin Inhibit Cardiac Fibrosis Induced by Phorbol 12-myristate 13-acetate

被引：0

作者：

WANG Yu Peng ^{[1
]}

WANG Ping ^{[2
]}

DONG Lei ^{[2
]}

CHEN Hui ^{[2
]}

WU Yong Quan ^{[2
]}

LI Hong Wei ^{[2
]}

LI Min ^{[1
]}

机构：

[1] Health and Heart Center, the Beijing Friendship Hospital affiliated the Capital Medical University

[2] Cardiovascular Center, the Beijing Friendship Hospital affiliated the Capital Medical University

来源：

BiomedicalandEnvironmentalSciences | 2014年 / 27卷 / 02期

关键词：

PKC; Figure; PMA; Relaxin Inhibit Cardiac Fibrosis Induced by Phorbol 12-myristate 13-acetate;

D O I：

暂无

中图分类号：

R542 [];

学科分类号：

1002 ; 100201 ;

摘要：

Relaxin is known to inhibit cardiac fibrosis.However,it is unclear whether relaxin could regulate the effects of Phorbol 12-myristate13-acetate(PMA,PKC activator)on cardiac fibrosis.So the influence of relaxin on the cell proliferation and collagen expression induced by PMA in cultured cardiac fibroblasts was studied.It showed that PMA significantly increased cardiac fibroblasts proliferation,Type I pro-collagen protein expression,Type I pro-collagen mRNA expression,and rhRLX absolutely significantly decreased PMA induced effects on cardiac fibroblasts proliferation and Type I pro-collagen expressions,indicating that relaxin could inhibit cardiac fibrosis induced by PMA.

引用

页码：138 / 141

页数：4

共 3 条

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