Changes of IL-8 and IL-8 mRNA after blast-fragment combined injury in dogs

被引：0
作者：
严家川
杨志焕
董蕻
冯刚
李晓炎
尹友国
机构：
来源：
JournalofMedicalCollegesofPLA | 2001年 / 02期
关键词：
blastinjury; fragmentinjury; blast-fragmentcombinedinjury; interleukin-8;
D O I：
暂无
中图分类号：
R392.1 [免疫生物学];
学科分类号：
100102 ;
摘要：
Objective:To explorethe characteristicsand the mechanismof the blast-fragmentcombinedinjury.Methods:Afterthedogswereinflictedwithhigh-velocityfragmentinjuryon theirlefthindlimbsafterblastinjury,theIL-8intheplasmaandlungtissuesupernatantswereassayedwithELISA,andtheexpressionof IL-8mRNAin lungtissuewas detectedwithin situ hybridization.Results:The levelsof IL-8in plasmaandlungtissueswere increasedafterblast,highvelocityfragmentandblast-fragmentcombinedinjuriesrespectively.IL-8mRNAwere upregulatedafterinjuries.Conclusion:IL-8may playa rolein theoccurrenceanddevelopmentof lunginjury.Detectingtheplasmalevelsof IL-8maybe quitehelpfulto estimatetheinjury.
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页码：83 / 85
页数：3
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