Effect of carvedilol on cardiac function and left ventricular remodeling in rats after acute myocardial infarction

被引：0
|
作者：
张军
贾国良
王海昌
机构：
[1] Department of Cardiovasology
[2] Xi’an 710033
[3] China
[4] Fourth Military Medical University
[5] Xijing Hospital
来源：
Journal of Medical Colleges of PLA | 2003年 / 02期
关键词：
carvedilol; myocardial infarction; collagen; left ventricular remodeling;
D O I：
暂无
中图分类号：
R542.22 [];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To observe the effect of carvedilol injection on left ventricular function and collagen remodelingin rat with myocardial infarction. Methods: Sixty rats with a model of myocardial infarction were randomly divided intonine groups. The rats of therapeutical group were treated with carvedilol injection (2 mg/d intraperitoneal injection)and/or captopil (2 g/L drinking water). Acute myocardial infaction (AMI) group did not receive drug treatment. Theanimals were sacrificed at 4 weeks and 8 weeks after coronary artery ligation. The levels of plasma angiotensin Ⅱ andplasma aldosterone and left ventricle function were determined at different time. The collagen content and the raio of
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页码：69 / 72 +76
页数：5
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