Effect of carvedilol on cardiac function and left ventricular remodeling in rats after acute myocardial infarction

被引：0
|
作者：
张军
贾国良
王海昌
机构：
[1] Department of Cardiovasology
[2] Xi’an 710033
[3] China
[4] Fourth Military Medical University
[5] Xijing Hospital
来源：
Journal of Medical Colleges of PLA | 2003年 / 02期
关键词：
carvedilol; myocardial infarction; collagen; left ventricular remodeling;
D O I：
暂无
中图分类号：
R542.22 [];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To observe the effect of carvedilol injection on left ventricular function and collagen remodelingin rat with myocardial infarction. Methods: Sixty rats with a model of myocardial infarction were randomly divided intonine groups. The rats of therapeutical group were treated with carvedilol injection (2 mg/d intraperitoneal injection)and/or captopil (2 g/L drinking water). Acute myocardial infaction (AMI) group did not receive drug treatment. Theanimals were sacrificed at 4 weeks and 8 weeks after coronary artery ligation. The levels of plasma angiotensin Ⅱ andplasma aldosterone and left ventricle function were determined at different time. The collagen content and the raio of
引用
收藏
页码：69 / 72 +76
页数：5
相关论文
共 50 条
  • [21] Does Spironolactone Have a Dose-Dependent Effect on Left Ventricular Remodeling in Patients with Preserved Left Ventricular Function After an Acute Myocardial Infarction?
    Vatankulu, Mehmet Akif
    Bacaksiz, Ahmet
    Sonmez, Osman
    Alihanoglu, Yusuf
    Koc, Fatih
    Demir, Kenan
    Gul, Enes Elvin
    Turfan, Murat
    Tasal, Abdurrahman
    Kayrak, Mehmet
    Yazici, Mehmet
    Ozdemir, Kurtulus
    CARDIOVASCULAR THERAPEUTICS, 2013, 31 (04) : 224 - 229
  • [22] MicroRNA-150: A Novel Marker of Left Ventricular Function and Remodeling After Acute Myocardial Infarction
    Devaux, Yvan
    Vausort, Melanie
    McCann, Gerry
    Kelly, Dominic
    Razvi, Naveed
    Zhang, Lu
    Ng, Leong L.
    Wagner, Daniel R.
    Squire, Iain B.
    CIRCULATION, 2012, 126 (21)
  • [23] Biomarker profiles as descriptors of left ventricular remodeling after acute myocardial infarction
    Lam, Phillip H.
    Anderson, Phillip R., III
    Ahmed, Bina
    Sobel, Burton E.
    VanBuren, Peter
    Schneider, David J.
    CORONARY ARTERY DISEASE, 2011, 22 (05) : 311 - 316
  • [24] Microvascular obstruction and left ventricular remodeling early after acute myocardial infarction
    Gerber, BL
    Rochitte, CE
    Melin, JA
    McVeigh, ER
    Bluemke, DA
    Wu, KC
    Becker, LC
    Lima, JAC
    CIRCULATION, 2000, 101 (23) : 2734 - 2741
  • [25] Therapy of left ventricular remodeling after myocardial infarction
    Auer, J
    Berent, R
    Eber, B
    ACTA MEDICA AUSTRIACA, 2001, 28 (05) : 117 - 122
  • [26] Prevention of left ventricular remodeling after myocardial infarction
    Martin St. John Sutton
    Victor A. Ferrari
    Current Treatment Options in Cardiovascular Medicine, 2002, 4 (2) : 97 - 108
  • [27] Comparative effects of cilazapril, carvedilol and their combination in preventing from left ventricular remodelling after acute myocardial infarction in rats
    Yang, YJ
    Tang, YD
    Ruan, YM
    Li, YL
    Zhou, YW
    Gao, RL
    Chen, JL
    Chen, ZJ
    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2002, 3 (01) : 31 - 35
  • [28] EflFect of hepatocyte growth factor on left ventricular remodeling after acute myocardial infarction in canine
    Ping LI
    Journal of Geriatric Cardiology, 2006, (02) : 112 - 115
  • [29] LEFT-VENTRICULAR REMODELING AFTER ACUTE MYOCARDIAL-INFARCTION - SOLVED AND UNSOLVED ISSUES
    BASSAND, JP
    EUROPEAN HEART JOURNAL, 1995, 16 : 58 - 63
  • [30] Left ventricular remodeling after experimental myocardial cryoinjury in rats
    Ciulla, MM
    Paliotti, R
    Ferrero, S
    Braidotti, P
    Esposito, A
    Gianelli, U
    Busca, G
    Cioffi, U
    Bulfamante, G
    Magrini, F
    JOURNAL OF SURGICAL RESEARCH, 2004, 116 (01) : 91 - 97
12345