The article examines the issues of regional security and prospects of cooperation between the countries of Central Asia in the context of a new world order. As factors of sustainable development and security, the author considers the following issues: preservation of the geopolitical balance in Central Asia; development of a multivariate system of transportation and communication corridors; cardinal increase in the efficiency of counterterrorism and religious extremism; a solution to the Afghan problem; and resolution to the problems of fair water use and ecology in the region.