Opuntia humifusa aqueous extract alleviates ethanol-induced gastric ulcer in a mouse model

被引：0
作者：
Chi-Yeol Yoo [1 ]
Hyeong-U Son [1 ,2 ]
Alshammari Fanar [1 ]
Hee-Jung Choi [1 ]
Md Badrul Alam [2 ]
Sang-Han Lee [1 ,2 ]
机构：
[1] Department of Food Science and Biotechnology, Kyungpook National University
[2] Food and Bio-Industry Research Institute, Kyungpook National University
来源：
Asian Pacific Journal of Tropical Biomedicine | 2020年 / 09期
关键词：
Opuntia humifusa; Gastric ulcer; Gastric lesions; Image analysis; Mucin;
D O I：
暂无
中图分类号：
R285.5 [中药实验药理];
学科分类号：
1008 ;
摘要：
Objective: To investigate the effect of Opuntia humifusa aqueous extract on gastric ulcers.Methods: An ethanol-induced model was used to examine the protective effect of Opuntia humifusa against gastric ulcers. The gastric ulcer index was evaluated via clinical observation and image analysis. Various inflammatory indicators were determined by RTPCR and Western blotting assays. Results: The gastric ulcer index was reduced to 8% in the group treated with Opuntia humifusa aqueous extract compared with that in the control group. RT-PCR analysis revealed that MUC5 AC expression was reduced to 39% in the control group compared with the non-treated group, whereas the omeprazole and Opuntia humifusa aqueous extract-treated groups increased the expression to 95% and 79%, respectively. Moreover, the expressions of various cytokines including TNF-α, IL-1β, and IL-6 were increased in the control group, while decreasing in Opuntia humifusa aqueous extract-treated group. Opuntia humifusa aqueous extract also suppressed the expressions of iN OS, COX-2, and its transcription factor NF-κB and increased mucus content considerably as compared to the control group. Conclusions: These results suggest that Opuntia humifusa aqueous extract is suitable as an alternative remedy for gastric ulcer treatment.
引用
收藏
页码：403 / 410
页数：8
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