AIEgen based light-up probes for live cell imaging

被引：0

作者：

Jing Liang ^{[1
]}

Guangxue Feng ^{[1
,2
]}

Ryan Tsz Kin Kwok ^{[3
]}

Dan Ding ^{[1
]}

Benzhong Tang ^{[3
,4
,5
,6
]}

Bin Liu ^{[1
,7
]}

机构：

[1] Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4

[2] NUS Environmental Research Institute, National University of Singapore, 5A Engineering Drive 1

[3] Department of Chemistry, Division of Biomedical Engineering, the Hong Kong University of Science and Technology

[4] SCUT-HKUST Joint Research Laboratory,Guangdong Innovative Research Team

[5] Institute of Materials Research Engineering,Agency for Science, Technology and Research, 3 Research Link

来源：

Science China(Chemistry) | 2016年 / 01期

基金：

新加坡国家研究基金会;

关键词：

aggregation-induced emission(AIE); light-up probe; live cell imaging; nucleus imaging; targeted cell imaging; AIE probes;

D O I：

暂无

中图分类号：

Q2-33 [细胞学实验与细胞学研究方法];

学科分类号：

071009 ; 090102 ;

摘要：

Fluorescent light-up probes comprising a tetraphenylethene unit with aggregation-induced emission(AIE)characteristics and a water-soluble peptide have been designed and synthesized which provide cell membrane and nuclear permeability to live cells.This strategy has offered new opportunities for the development of probes with light-up ability and good signal-to-noise ratio.The selectivity or targeting specificity is determined by the peptide sequence,i.e.a nuclear localization signal that leads to nucleus imaging and a cell biomarker targeting peptide that offers specific light-up imaging of HT-29 cells.

引用

页码：53 / 61

页数：9

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