IL-17的信号传导及功能研究

被引：97
|
作者：
施沛青
朱书
钱友存
机构：
[1] 中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所
来源：
中国细胞生物学学报 | 2011年 / 33卷 / 04期
关键词：
白介素17(IL-17); TH17细胞; 宿主防御; 自身免疫;
D O I：
暂无
中图分类号：
R363 [病理生理学];
学科分类号：
摘要：
白介素17（IL-17）,辅助性T细胞TH17分泌的特征性细胞因子,在抵抗胞外细菌、真菌感染的宿主防御以及各种自身免疫性疾病发病中起到了重要的作用。本文对TB17细胞、IL-17的发现作了历史性回顾,并综述了IL-17受体介导的信号传导途径和生理功能的研究进展,为TH17细胞、IL-17及其受体作为药物治疗的新靶点提供新思路。
引用
收藏
页码：345 / 357
页数：13
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