Design,synthesis and antitumor activity of 3-substituted quinolone derivatives (Ⅰ)

被引：1
作者：
Hua Wang Qi Dong You Zhi Yu Li Yi Quan Zou Department of Medicinal Chemistry
机构：
来源：
Chinese Chemical Letters | 2008年 / 19卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Quinolone derivatives; Synthesis; Antitumor;
D O I：
暂无
中图分类号：
O625.31 [酚及其衍生物];
学科分类号：
070303 ; 081704 ;
摘要：
A series of quinolone derivatives containing benzimidazole,benzoxazole or benzothiazole ring were synthesized.The cytotoxicity of 12 new compounds was evaluated in KB,Be17402,A2780 and HT-29 cell lines.Most of synthesized compounds showed moderate inhibitory activity against cancer cells.The inhibitory activities of 6k,against KB and A2780 tumor cells are comparable to that of topotecan,one of topoisomeraseⅠinhibitors.
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收藏
页码：1395 / 1397
页数：3
相关论文
共 12 条
  • [1] H.Koga,A.Itob,S.Murayama,et al. J.Meal.Chem . 1980
  • [2] H.J.Park,Y.S.Kim,J.S.Kim,et al. Bioorg.IVied.Chem.Lett . 2004
  • [3] B.K.Sinha. Drugs . 1995
  • [4] The Use of Polyphosphoric Acid in the Sythesis of 2-Aryl-substituted Benzimid-azoles,Benzoxzoles and Benzothiazoles. Hein,D.W,R.J　Alheim,J.J.Leavitt. Journal of the American Chemical Society . 1957
  • [5] Effects of novel fluoroquinolones on the catalytic activities of eukaryotic Topisomerasell.Influence of the C-8 fluorine group. Robinson MJ,Martin BA,Gootz TD,et al. Antimicrobial Agents and Chemotherapy . 1992
  • [6] Structure–activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons. Kim,JS,Sun,Q,Gatto,B,Yu,C,Liu,A,Liu,LF,LaVoie,EJ. Bioorganic and Medicinal Chemistry . 1996
  • [7] DNA topoisomerase poisons as antitumor drugs. Liu,LF. Annual Review of Biochemistry . 1989
  • [8] I.Mozk,B.Sket. J.Heterocycl.Chem . 1994
  • [9] L.A.Mitscher,H.E.Gracey,G.W.Clark,et al. J.Meal.Chem . 1978
  • [10] M.R.Redinbo,J.J.Champoux,G.J.Wire. Biochemistry . 2000
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