来氟米特与霉酚酸酯治疗难治性肾病综合征的对照观察

被引：14
|
作者：
汤力
曹雪莹
赵威
王顺泽
刘旭利
刘志国
陈香美
机构：
[1] 解放军总医院肾病科解放军肾病中心暨重点实验室
来源：
北京医学 | 2004年 / 05期
关键词：
来氟米特; 霉酚酸酯; 难治性肾病综合征;
D O I：
10.15932/j.0253-9713.2004.05.004
中图分类号：
R692 [肾疾病];
学科分类号：
摘要：
目的　观察来氟米特 (LEF)对激素治疗无效或复发的难治性肾病综合征的疗效及安全性。方法　 6 0例难治性肾病综合征患者随机分为两组 ,实验组接受LEF治疗 ,对照组接受霉酚酸酯 (MMF)治疗。观察治疗后 12周及 2 4周的相关临床指标变化 ,并进行评价。结果　治疗 12周后LEF组总有效率为 6 9.9% ,与MMF组疗效无显著性差异 (P >0 .0 5 )。治疗 2 4周 ,LEF组血清白蛋白、2 4h尿蛋白定量均有明显改善 (P <0 .0 5 ) ,LEF组总有效率为 86 .6 % ,两组相比无显著性差异 (P >0 .0 5 )。两组患者均耐受良好。结论　来氟米特能够有效的缓解难治性肾病综合征。
引用
收藏
页码：297 / 299
页数：3
相关论文
共 11 条
  • [1] Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Herrmann ML,Schleyerbach R,Kirschbaum BJ. Immunopharmacology . 2000
  • [2] Pharmacologicallyinducedregessionofchronictransplantrejection. XiaoF,ChongA,ShenJ ,etal. Transplantation . 1995
  • [3] Pulse cyclophosphamide therapy in frequently relapsing nephritic syndrome. Gulati S,Pokhariyal S,Sharma RK,et al. Nephrology Dialysis Transplantation . 2001
  • [4] Mechanisms of action of cyclophosphamide as a male-mediated developed toxicant. Robaire B,Hales BF. Advances in Experimental Medicine and Biology . 2003
  • [5] Guidelines for the management of refractory nephritic syndrome-form investigations between 1997 and 2001 research projectteam for progressive renal lesions in the Ministry of Health, Labor and Welfare, Japan. Sakai H,Kurolkawa K,Saito T,et al. Nippon Jinzo Gakkai Shi . 2002
  • [6] Leflunomide-a new drug for pharmacological immunomodulation. Wozel G,feiffer C. Hautarzt . 2002
  • [7] Leflunomidesuppresses TNF-induced cellular responses: effect on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. Manna SK,Mukhopadhyay A,Aggarawal BB. J Immunol . 2000
  • [8] Immunosupressive Leflunomide metabolite(A771726)blocks TNF-dependent nuclear factor-k B activation and gene expression. Manna SK,Aggarwal BB. Immunology . 1999
  • [9] Activation of transcription factor NF - Kappa B in experimental glomerulonephritis in rats. Sakurai H,Hisada Y,Ueno M,et al. Biochimica et Biophysica Acta . 1996
  • [10] Therapeutic effects of leflunomdie, a new antitheumatic drug, on glomerulonephritis induced by the antibasement membrane antibody in rats. Ogawa T,Inazu M,Gotoh K,et al. Clinical Immunology . 1991
12