Kanglaite combined Gemcitabine inhibits growth of nude mouse subcutaneous transplantation tumor of human PC-3 pancreatic cancer cell

被引：0
|
作者：
王伟
金建光
秦兆寅
机构：
[1] Henan Science and Technology University
[2] Luoyang 471003
[3] Xi’an 710004
[4] Xi’an Jiaotong University
[5] China
[6] Department of General Surgery
[7] First Hospital
[8] Second Hospital
来源：
Journal of Medical Colleges of PLA | 2005年 / 04期
关键词：
human PC-3 pancreatic cancer; nude mouse subcutaneous transplantation tumor; apoptosis; immunohistochemisry; bcl-2; Bax; VEGF;
D O I：
暂无
中图分类号：
R735.9 [胰腺肿瘤];
学科分类号：
100214 ;
摘要：
Objective:To study the mechanisms of pancreatic cancer treatment with Kanglaite combined Gemcitabine by investigating the relationship between the apoptosis and the expression of bcl-2, Bax and VEGF in pancreatic cancer cells.Methods:Nude mouse subcutaneous transplantation tumor model of Human PC-3 pancreatic cancer was established; the expressions of bcl-2, Bax and VEGF of transplantation tumor cell were determined; the earlier apoptosis rate of pancreatic cancer cell and the gross tumor volume were determined. Results:Kanglaite combined Gemcitabine remarkably decreased the protein expression of bcl-2,raised the expression of Bax,increased the apoptosis rate of the pancreatic cancer and contract the gross tumor volume. Kanglaite greatly decreased the protein expression of VEGF of the tumor cell. Conclusion:Therapeutic efficacy of Kanglaite combined Gemcitabine is far better than separate use of the two medicines in the pancreatic cancer transplantation tumor treatment.
引用
收藏
页码：219 / 222 +235
页数：5
相关论文
共 50 条
  • [21] Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3
    Samarghandian, Saeed
    Afshari, Jalil Tavakkol
    Davoodi, Saeideh
    CLINICS, 2011, 66 (06) : 1073 - 1079
  • [22] Etoposide sensitivity of human prostatic cancer cell lines PC-3, DU 145 and LNCaP
    Salido, M
    Larrán, J
    López, A
    Vilches, J
    Aparicio, J
    HISTOLOGY AND HISTOPATHOLOGY, 1999, 14 (01) : 125 - 134
  • [23] Anticancer mechanism of Sinapic acid in PC-3 and LNCaP human prostate cancer cell lines
    Eroglu, Canan
    Avci, Ebru
    Vural, Hasibe
    Kurar, Ercan
    GENE, 2018, 671 : 127 - 134
  • [24] Reduction of oxidative stress and ornithine decarboxylase expression in a human prostate cancer cell line PC-3 by a combined treatment with α-tocopherol and naringenin
    Torricelli, Piera
    Elia, Antonia Concetta
    Magara, Gabriele
    Feriotto, Giordana
    Forni, Cinzia
    Borromeo, Ilaria
    De Martino, Angelo
    Tabolacci, Claudio
    Mischiati, Carlo
    Beninati, Simone
    AMINO ACIDS, 2021, 53 (01) : 63 - 72
  • [25] Matrine inhibits proliferation and induces apoptosis of the androgen-independent prostate cancer cell line PC-3
    Zhang, Peng
    Wang, Ziming
    Chong, Tie
    Ji, Zongzheng
    MOLECULAR MEDICINE REPORTS, 2012, 5 (03) : 783 - 787
  • [26] Demethylzeylasteral (ZST93) inhibits cell growth and enhances cell chemosensitivity to gemcitabine in human pancreatic cancer cells via apoptotic and autophagic pathways
    Wang, Feng
    Tian, Xiaodong
    Zhang, Zhengkui
    Ma, Yongsu
    Xie, Xuehai
    Liang, Jian
    Yang, Chunxin
    Yang, Yinmo
    INTERNATIONAL JOURNAL OF CANCER, 2018, 142 (09) : 1938 - 1951
  • [27] Zhao's Weitiao No 3 inhibits tumor growth in gastric cancer-bearing nude mice
    Pan, Qi
    Xiang, Pei
    Chen, Yuanyuan
    Zhao, Jingfang
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2022, 21 (11) : 2385 - 2389
  • [28] Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3)
    Senthilkumar, Kalimuthu
    Arunkumar, Ramachandran
    Elumalai, Perumal
    Sharmila, Govindaraj
    Gunadharini, Dharmalingam Nandhagopal
    Banudevi, Sivanantham
    Krishnamoorthy, Gunasekar
    Benson, Chellakan Selvanesan
    Arunakaran, Jagadeesan
    CELL BIOCHEMISTRY AND FUNCTION, 2011, 29 (02) : 87 - 95
  • [29] Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer
    Chen, Wanyuan
    Fan, Weimin
    Ru, Guoqing
    Huang, Fang
    Lu, Xiaming
    Zhang, Xin
    Mou, Xiaozhou
    Wang, Shibing
    ONCOLOGY REPORTS, 2019, 41 (01) : 67 - 76
  • [30] A novel HDAC inhibitor, CG200745, inhibits pancreatic cancer cell growth and overcomes gemcitabine resistance
    Lee, Hee Seung
    Park, Soo Been
    Kim, Sun A.
    Kwon, Sool Ki
    Cha, Hyunju
    Lee, Do Young
    Ro, Seonggu
    Cho, Joong Myung
    Song, Si Young
    SCIENTIFIC REPORTS, 2017, 7
12345