Synthesis of bromoallenyl pyrrolidines via 1,4-addition to 1,3-enynes

被引：0
|
作者：
WERNESS Jenny B. [1 ]
TANG WeiPing [2 ]
机构：
[1] Department of Chemistry, University of Wisconsin
[2] School of Pharmacy, University of Wisconsin
来源：
Science China(Chemistry) | 2011年 / 54卷 / 01期
关键词：
halocyclization; halogenation; conjugated enynes; allene; bromoallene; pyrrolidine;
D O I：
暂无
中图分类号：
O621.3 [有机合成化学];
学科分类号：
摘要：
The discovery of the novel reactivity of conjugated enynes,mediated by readily available halogenation reagents,opens a broad range of mechanistically unique pathways for the synthesis of highly functionalized chiral allene derivatives.Bromoallenyl pyrrolidines can be synthesized via 1,4-addition of sulfonamide nitrogen nucleophiles and halogens to conjugated enynes.This process can lead to simultaneous formation of a highly functionalized axially chiral allene and a stereogenic center under economical and environmentally friendly reaction conditions.
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页码：56 / 60
页数：5
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