Preparation of Chitosan-based Microspheres for Rapid Hemostasis

被引：0

作者：

Yan Fang ^{[1
]}

Peiyuan Li ^{[1
]}

Weikang Zhou ^{[1
]}

机构：

[1] Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University

来源：

Paper and Biomaterials | 2021年 / 6卷 / 01期

关键词：

D O I：

暂无

中图分类号：

O636.1 [高分子多聚糖]; R318.08 [生物材料学];

学科分类号：

070305 ; 0805 ; 080501 ; 080502 ; 081704 ;

摘要：

Rapid control of heavy hemorrhaging is critical to save the life of injured individuals. Herein, we developed a novel hemostat employing chitosan-based microspheres, which was prepared by sequential microemulsion of chitosan solution, sol-gel phase transition, and surface modification by 3, 4-dihydroxyhydrocinnamic acid(HCA). HCA-modified chitosan microspheres(CSMS-HCA) displayed a porous structure, with a high specific surface area(～211.3 m~2/g), accelerating their rapid absorption of blood and concentrating red cells and platelets. The CSMS-HCA exhibited much better in vitro and in vivo hemostatic efficacy than porous chitosan microspheres did. Such a rapid hemostat in the form of microspheres is highly effective in treating deep and irregular wounds, owing to easy accessibility to injured sites.

引用

页码：41 / 49

页数：9

共 17 条

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