Preparation of Chitosan-based Microspheres for Rapid Hemostasis

被引：0

作者：

Yan Fang

Peiyuan Li

Weikang Zhou

机构：

[1] FujianProvincialKeyLaboratoryofPolymerMaterials,CollegeofChemistryandMaterialsScience,FujianNormalUniversity

来源：

Paper and Biomaterials | 2021年 / 6卷 / 01期

关键词：

D O I：

暂无

中图分类号：

O636.1 [高分子多聚糖]; R318.08 [生物材料学];

学科分类号：

070305 ; 080501 ; 081704 ; 0805 ; 080502 ;

摘要：

Rapid control of heavy hemorrhaging is critical to save the life of injured individuals. Herein, we developed a novel hemostat employing chitosan-based microspheres, which was prepared by sequential microemulsion of chitosan solution, sol-gel phase transition, and surface modification by 3, 4-dihydroxyhydrocinnamic acid（HCA）. HCA-modified chitosan microspheres（CSMS-HCA） displayed a porous structure, with a high specific surface area（～211.3 m2/g）, accelerating their rapid absorption of blood and concentrating red cells and platelets. The CSMS-HCA exhibited much better in vitro and in vivo hemostatic efficacy than porous chitosan microspheres did. Such a rapid hemostat in the form of microspheres is highly effective in treating deep and irregular wounds, owing to easy accessibility to injured sites.

引用

页码：41 / 49

页数：9

共 17 条

[1] Synthetic poly(vinyl alcohol)-chitosan as a new type of highly efficient hemostatic sponge with blood-triggered swelling and high biocompatibility [J].

Zhao, Yi-Fan ;

Zhao, Jing-Yu ;

Hu, Wen-Zhi ;

Ma, Kui ;

Chao, Yong ;

Sun, Peng-Jun ;

Fu, Xiao-Bing ;

Zhang, Hong .

JOURNAL OF MATERIALS CHEMISTRY B, 2019, 7 (11) :1855-1866

[2]

Wearable, Healable, and Adhesive Epidermal Sensors Assembled from Mussel‐Inspired Conductive Hybrid Hydrogel Framework[J] . Meihong Liao,Pengbo Wan,Jiangru Wen,Min Gong,Xiaoxuan Wu,Yonggang Wang,Rui Shi,Liqun Zhang.Advanced Functional Materials . 2017 (48)

[3] Design and development of polysaccharide hemostatic materials and their hemostatic mechanism [J].

Yang, Xiao ;

Liu, Wen ;

Li, Na ;

Wang, Mingshan ;

Liang, Bin ;

Ullah, Ihsan ;

Neve, Agnaldo Luis ;

Feng, Yakai ;

Chen, Hao ;

Shi, Changcan .

BIOMATERIALS SCIENCE, 2017, 5 (12) :2357-2368

[4]

Tough, self-healable and tissue-adhesive hydrogel with tunable multifunctionality[J] . Lu Han,Liwei Yan,Kefeng Wang,Liming Fang,Hongping Zhang,Youhong Tang,Yonghui Ding,Lu-Tao Weng,Jielong Xu,Jie Weng,Yujie Liu,Fuzeng Ren,Xiong Lu.NPG Asia Materials . 2017 (4)

[5] An Underwater Surface-Drying Peptide Inspired by a Mussel Adhesive Protein [J].

Wei, Wei ;

Petrone, Luigi ;

Tan, YerPeng ;

Cai, Hao ;

Israelachvili, Jacob N. ;

Miserez, Ali ;

Waite, J. Herbert .

ADVANCED FUNCTIONAL MATERIALS, 2016, 26 (20) :3496-3507

[6] Underwater contact adhesion and microarchitecture in polyelectrolyte complexes actuated by solvent exchange [J].

Zhao, Qiang ;

Lee, Dong Woog ;

Ahn, B. Kollbe ;

Seo, Sungbaek ;

Kaufman, Yair ;

Israelachvili, Jacob N. ;

Waite, J. Herbert .

NATURE MATERIALS, 2016, 15 (04) :407-+

[7]

Microspheres of carboxymethyl chitosan, sodium alginate and collagen for a novel hemostatic in vitro study[J] . Xinyi Shi,Qiang Fang,Miao Ding,Jing Wu,Fei Ye,Zhengbing Lv,Jia Jin.Journal of Biomaterials Applications . 2016 (7)

[8] Management of acute variceal bleeding using hemostatic powder [J].