Two new b-hydroxy amino acid-coupled secoiridoids from the flower buds of Lonicera japonica:Isolation,structure elucidation,semisynthesis,and biological activities

被引：25

作者：

Wei-Xia Song ^{[1
]}

Yong-Chun Yang ^{[1
]}

Jian-Gong Shi ^{[1
]}

机构：

[1] State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College

来源：

ChineseChemicalLetters | 2014年 / 25卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Lonicera japonica; Caprifoliaceae; b-Hydroxy amino acid-coupled secoirridoid; Isolation; Structure elucidation; Semisynthesis; Biological activity;

D O I：

暂无

中图分类号：

R284.1 [化学分析与鉴定];

学科分类号：

1008 ;

摘要：

Two new b-hydroxy amino acid-coupled secoiridoids,named serinosecologanin(1) and threoninosecologanin(2),were isolated from an aqueous extract of the flower buds of Lonicera japonica.Their uncommon structures including absolute configurations were determined by spectroscopic data analysis,and confirmed by semisynthesis from the co-occurring secologanin(3) and secologanic acid(4).Compounds 1 and 2 exhibited resistant activity against b-glucosidase from almonds and hesperidinase from Aspergillus niger,they also showed activity against the release of glucuronidase in rat polymorphonuclear leukocytes induced by the platelet-activating factor with inhibition rates of(34.9 3.1)% and(53.6 2.6)%,respectively.

引用

页码：1215 / 1219

页数：5

共 3 条

[1]

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[2]

Two Triterpenoid Saponins from Lonicera Japonica[J]. Rong Wei TENG;De Zu WANG;Chang Xiang CHEN (Kunming Institute of Botany. Chinese Academic of Sciences. Kunming 650204).Chinese Chemical Letters. 2000(04)

[3]

Isolation of secoiridoid artifacts from Lonicera japonica .2 Tomassini L,Cometa MF,Serafini M,Nicoletti M. Journal of Natural Products . 1995

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