Effect of beta-tricalcium phosphate/poly-l-lactide composites on radial bone defects of rabbit

Objective:To explore the effect ofβ-TCP/PLLA scaffold in repairing rabbit radial lone defects.Methods:Thirty New Zealand rabbits were divided intoβ-TCP/PLLA group(group A),pure PLLA group(group B)and contrast group(group C)randomly.The rabbits were sacrificed respectively after 4.8.12,24 weeks and the X-ray film was performed at the same time to evaluate the repair effect in different groups.Retiults:X-ray film showed there was uneven low density bone callus development in defect region after 4 weeks in group A.The defect region was filled with neonate osseous tissue completely during 12-24 weeks.X-ray score revealed that repair of bone defect results significantly better than group B and group C.Conclusions:Theβ-PCP/PLLA composite is capable of repairing radial lone lone defects.β-TCP/PLLA scaffold is significant because of rapid degradation ability,good histocompatihility and osteogenic action.