Synthesis and biological evaluation of indole-3-carboxamide derivatives as antioxidant agents

被引：0

作者：

Erfang Huang ^{[1
]}

Lan Zhang ^{[1
]}

Chuying Xiao ^{[2
]}

Guangpeng Meng ^{[1
]}

Bingqi Zhang ^{[1
]}

Jianshu Hu ^{[2
]}

David ChiCheong Wan ^{[2
]}

Qingguo Meng ^{[3
]}

Zhe Jin ^{[1
]}

Chun Hu ^{[1
]}

机构：

[1] Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University

[2] School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong

[3] Department of Pharmacy, Yantai Univeristy

来源：

ChineseChemicalLetters | 2019年 / 30卷 / 12期

关键词：

Heterocycle; Melatonin; Indole-3-carboxamide derivatives; Synthesis; Antioxidant activity; Structure-activity relationship;

D O I：

暂无

中图分类号：

O626.1 [含单异原子的五节杂环];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidative stress results in various pathologies and as consequence antioxidant agents have attracted uninterrupted attention.In this paper,a novel series of indole-3-carboxamide derivatives（6 a-61） were designed and synthesized based on the melatonin structure as novel antioxidants.All of them were evaluated for the antioxidant activities in vitro against human neuroblastoma SH-SY5 Y cell line using H2 O2 radical scavenging assay.The target compounds 6 a,6 f and 6 i indicated better activities than the positive control,ascorbic acid,and 6 a exhibited the best antioxidant activity.In addition,the structureactivity relationships of the target compounds were also preliminarily summarized based on the obtained experimental data.

引用

页码：2157 / 2159

页数：3