Highly chemoselective lipase from Candida sp.99-125 catalyzed ring-opening polymerization for direct synthesis of thiol-terminated poly(e-caprolactone)

被引：2

作者：

Ning Zhu ^{[1
]}

ZiLong Zhang ^{[1
]}

Wei He ^{[1
]}

XiaoCheng Geng ^{[1
]}

Zheng Fang ^{[2
]}

Xin Li ^{[1
]}

ZhenJiang Li ^{[1
,3
]}

Kai Guo ^{[1
,3
]}

机构：

[1] College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University

[2] School of Pharmaceutical Sciences,Nanjing Tech University

[3] State Key Laboratory of Materials-Oriented Chemical Engineering,Nanjing Tech University

来源：

ChineseChemicalLetters | 2015年 / 26卷 / 03期

关键词：

Thiol; Poly(e-caprolactone); Lipase from candida sp.99-125; Chemoselective; Ring-opening polymerization;

D O I：

暂无

中图分类号：

O633.14 [聚酯];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Lipase from Candida sp.99-125 catalyzed ring-opening polymerization of e-caprolactone in the presence of 6-mercapto-1-hexanol was presented as a new metal-free approach for direct synthesis of welldefined thiol-terminated poly(e-caprolactone).Remarkably,high chemoselectivity of lipase from Candida sp.99-125 toward hydroxyl and thiol was exhibited and quantitative thiol fidelity over 90% was achieved.The tedious protecting/deprotecting steps for thiol and metal residue were avoided.The polymerizations with around 70% monomer conversion were conducted in bulk and toluene at relative low temperature of 40 8C.Number–average molecular weight of resulted polymers ranged from 3000 to4700 Da by changing the feed ratio between monomer and initiator.The structures of obtained thiolterminated poly(e-caprolactone) were demonstrated by combining NMR and SEC analyses.

引用

页码：361 / 364

页数：4

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