Detection of D2-40 monoclonal antibody-labeled lymphatic vessel invasion in esophageal squamous cell carcinoma and its clinicopathologic significance

被引:0
作者
Bing Bai [1 ,2 ]
Wei Ma [1 ]
Kai Wang [3 ]
Sita Ha [4 ]
Jian-Bo Wang [1 ]
Bing-Xu Tan [1 ]
Na-Na Wang [1 ]
Sheng-Si Yang [1 ]
Yi-Bin Jia [1 ]
Yu-Feng Cheng [1 ]
机构
[1] Department of Radiation Oncology, Qilu Hospital of Shandong University
[2] Department of Oncology, Yiyuan Chi- nese Medicine Hospital
[3] Department of Oncology, Wendeng Central Hospital
[4] Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University
关键词
Esophageal squamous cell carcinoma; lymphatic vessel invasion; D2-40; lymph node metastasis; prognosis;
D O I
暂无
中图分类号
R735.1 [食管肿瘤];
学科分类号
100214 ;
摘要
Objective: This study aims to investigate the clinicopathologic significance of lymphatic vessel invasion (LVI) labeled by D2-40 monoclonal antibody in esophageal squamous cell carcinoma (ESCC). Methods: Immunohistochemical assay was used to detect the expression of D2-40 and LVI in 107 ESCC patients. Then, the correlation between the clinicopathologic feature and the overall survival time of the patients was analyzed. Results: The lymph node metastasis rates were 70% and 21% in the LVI-positive and LVI-negative groups, respectively. The nodal metastasis rate was higher in the LVI-positive group than in the LVI-negative group. Multivariate regression analysis showed that LVI was related to nodal metastasis (P<0.001). The median survival time of the patients was 26 and 43 months in the LVI-positive and LVI-negative groups, respectively. Although univariate regression analysis showed significant difference between the two groups (P=0.014), multivariate regression analysis revealed that LVI was not an independent prognostic factor for overall survival in the ESCC patients (P=0.062). Lymphatic node metastasis (P=0.031), clinical stage (P=0.019), and residual tumor (P=0.026) were the independent prognostic factors. Conclusion: LVI labeled by D2-40 monoclonal antibody is a risk factor predictive of lymph node metastasis in ESCC patients.
引用
收藏
页码:81 / 85
页数:5
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