p27kip1与膀胱肿瘤

被引:0
|
作者
王洋
施国伟
何家扬
机构
[1] 复旦大学附属上海市第五人民医院泌尿外科上海
关键词
膀胱肿瘤; 基因;
D O I
暂无
中图分类号
R737.14 [膀胱肿瘤];
学科分类号
摘要
p27kip1作为重要的CDKs抑制因子,对细胞周期进行负调控,具有抑癌作用。许多研究表明,p27kip1是多种人类肿瘤中独立的预后因子,可作为临床诊断的标志,并在膀胱肿瘤的诊断与治疗方面也发挥作用。本文将对p27kip1的主要功能、作用机制及其在膀胱肿瘤诊断和治疗方面的应用作一综述。
引用
收藏
页码:452 / 455
页数:4
相关论文
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  • [1] Croix B,Florenes VA,Rak JW,et al.Impact of the cyclin-dependent kinase inhibitor p27 kip 1 on resistance of tumor cells to anti- cancer agents. Nature Medicine . 1996
  • [2] Lenz HJ.Clinical update: proteasome inhibitory in solid tumors. Cancer Treatment Reviews . 2003
  • [3] Achenbach TV,Muller R,Slater EP.Synergistic antitumor effect of chemotherapy and antisense- mediated ablation of the cell cycle inhibitor p27kip1. Clinical Cancer Research . 2000
  • [4] Kamai1 T,Takagi K,Asami H,et al.Decreasing of p27Kip1 and cyclin E protein levels is associated with progression from superficial into invasive bladder cancer. British Journal of Cancer . 2001
  • [5] Hsieh FF,Bamett LA,Green WF,et al.Cell cycle exit during terminal erythroid differentiation is associated with accumulation of p27(kip1) and inactivation of cdks kinase. Blood . 2000
  • [6] Park KH,Seol JY,Yoo CG,et al.A denovirus expressiong p27kip1 induces growth arrest of lung cancer cell lines and suppresses the growth of established lung cancer xenografts. Lung Cancer . 2001
  • [7] Chem J,Willingham T,Shuford M,et al.The expression of p27kip1 in cell cycle. Science . 1996
  • [8] So AI,Larue H,Lacombe L,et al.Significance of cyclin-dependent kinase inhibitor p27kip1 expression in superficial bladder tumors. Journal d Urologie . 2000
  • [9] Katayose Y,KimM,Rakkar AN,et al.Promoting apoptosis: a novel activity associated with the cyclin - dependent kinase inhibitor p27. Cancer Research . 1997
  • [10] Naumann U,Weit S,Rieger L,et al.p27 modulates cell cycle progression and chemosensitivity in human malignantglioma. Biochemistry and Biophysics . 1999