First total synthesis of eudistalbin A

被引：0
作者：
Pu Yong ZhangJun Lei WangSheng Biao WanTao Jiang School of Medicine and PharmacyKey Laboratory of Marine DrugsMinistry of Education Ocean University of ChinaQingdao China [266003 ]
机构：
来源：
Chinese Chemical Letters | 2010年 / 21卷 / 08期
关键词：
β-Carboline; Eudistalbin A; Pictet-Spengler reaction; Henry reaction; Total synthesis;
D O I：
暂无
中图分类号：
TQ464 [生物制品药物的生产];
学科分类号：
100705 ;
摘要：
<正>Eudistalbin A was isolated from marine tunicate eudistoma album and possess cytotoxic activity(ED50<3.2μg/mL) in vitro against the growth of KB human buccal carinoma cells.The synthetic eudistalbin A showed potent inhibitory activity against the breast carcinoma cell line MDA-231 with an IC50 value of 2.1μmol/L using the metabolic assay MTT.All structures of new compounds were confirmed by 1H NMR,13C NMR,HRMS and optical rotation.
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页码：889 / 891
页数：3
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