Gene Expression Profile of Human Skeletal Muscle and Adipose Tissue of Chinese Han Patients with Type 2 Diabetes Mellitus

被引：0

作者：

YANLI YANG RUOLAN XIANG CHANG YANG XIAOJUN LIU WENJUN SHEN JIN ZUO YONGSHENG CHANG AND FUDE FANG Department of Internal Medicine Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China ^{[2
,2
,3
,3
,100730
]}

Department of Physiology and Pathophysiology Peking University Health Science Center Beijing China ^{[100083
]}

National Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences Beijing China ^{[100005
]}

Division of Endocrinology Stanford University and VA Palo Alto Health Care System Miranda Avenue Palo Alto CA USA ^{[3801
,94304
]}

机构：

来源：

BiomedicalandEnvironmentalSciences | 2009年 / 22卷 / 05期

关键词：

Type 2 diabetes mellitus (T2DM); Microarray technology; Skeletal muscle; Adipose tissue;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus (T2DM) patients and healthy subjects using DNA microarray analysis. Methods T2DM patiens were divided into female group, young male group and old male group. DNA microarray analysis and quantitative real-time PCR were carried out to analyze the relation between gene expressions and T2DM. Results The mRNA expression of 298, 578, and 350 genes was changed in the skeletal muscle of diabetes mellitus patients compared with control subjects. The 1320, 1143, and 2847 genes were modified in adipose tissue of the three groups. Among the genes surveyed, the change of 25 and 39 gene transcripts in skeletal muscle and adipose tissue was ≥2 folds. These differentially expressed genes were classified into 15 categories according to their functions. Conclusion New genes are found and T2DM can be prevented or cured.

引用

页码：359 / 368

页数：10

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