Suitability of the woodchuck HCC as a preclinical model for evaluation of intra-arterial therapies

被引：0

作者：

Alexander YKim ^{[1
]}

Joseph HYacoub ^{[1
]}

David HField ^{[1
]}

Byoung Uk Park ^{[2
]}

Bhaskar Kallakury ^{[2
]}

Kyle EKorolowicz ^{[3
]}

Stephan Menne ^{[3
]}

机构：

[1] Department of Radiology,Medstar Georgetown University Hospital

[2] Department of Pathology and Laboratory Medicine,Medstar Georgetown University Hospital

[3] Department of Microbiology and Immunology,Georgetown University Medical Center

来源：

Animal Models and Experimental Medicine | 2020年 / 3卷 / 01期

关键词：

angiography; animal model; hepatocellular carcinoma; woodchuck;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤]; R-332 [医用实验动物学];

学科分类号：

100214 ; 1001 ;

摘要：

The most commonly used preclinical models of hepatocellular carcinoma(HCC) are limited for use in testing of intra-arterial therapies such as transarterial chemoembolization and radioembolization.Issues encountered with the more commonly used animal models include dissimilarity in their disease development compared with humans and the size of the vasculature which can make intra-arterial therapy testing difficult or impossible.Here we describe the suitability of the woodchuck HCC model for testing of intra-arterial therapies.We describe the techniques for pre-embolization imaging assessment using CT and MRI,technical tips on performing angiography and embolization,and pathological assessment of treated liver.

引用

页码：98 / 102

页数：5