One-pot photoreduction to prepare NIR-absorbing plasmonic gold nanoparticles tethered by amphiphilic polypeptide copolymer for synergistic photothermal-chemotherapy

被引：0

作者：

Siqi Yang ^{[1
]}

Linzhu Zhou ^{[1
]}

Yue Su ^{[1
]}

Rong Zhang ^{[2
]}

Chang-Ming Dong ^{[1
,2
]}

机构：

[1] School of Chemistry and Chemical Engineering, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University

[2] Joint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai Fengxian Central Hospital

来源：

ChineseChemicalLetters | 2019年 / 30卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Near infrared; Plasmonic gold nanoparticles; Polypeptide; Photothermal therapy; Combination therapy;

D O I：

暂无

中图分类号：

O614.123 [金Au]; TB383.1 [];

学科分类号：

070205 ; 070301 ; 080501 ; 081704 ; 1406 ;

摘要：

We developed one-pot photoreduction strategy to prepare near infrared light（NIR）-absorbing plasmonic gold nanoparticles（Au NPs） tethered by amphiphilic polypeptide copolymer poly（L-cysteine）-b-poly（ethylene oxide）(PLC-b-PEO). The PLC-b-PEO@Au NPs possessed strong NIR absorption at 700–1100 nm and ultrahigh photothermal conversion efficiency of 62.1%. Upon the NIR irradiation（808nm,2 W/cm;,5 min）, the PLC-b-PEO@Au NPs（1mg/mL） sharply attained an elevation of 30.8℃ and the hyperthermia effect could efficiently kill cancer cells in vitro. As for the PT-CT treatment, the doxorubicin（DOX）-loaded nanoparticles of DOX-PLC-b-PEO@Au NPs gave a combination index of 0.9 compared to single chemotherapy（CT） or photothermal therapy（PT）, demonstrating a synergistic effect.

引用

页码：187 / 191

页数：5