TWO-SITE PROPERTY OF THENOYLTRIFLUOROACETONE INHIBITING SUCCINATE-UBIQUINONE REDUCTASE

被引：0

作者：

徐建兴

TSOO E.KING

机构：

[1] University City Science Center and Department of Biochemistry and Biophysics

[2] Beijing 100080

[3] Philadelphia PA 19104

[4] Academia Sinica

[5] PRC

[6] University of Pennsylvania

[7] Institute for Structural and Functional Studies

[8] Institute of Biophysics

来源：

Science in China,SerB . | 1992年 / Ser.B . 1992查看该刊数据库收录来源卷 / 02期

基金：

中国国家自然科学基金;

关键词：

succinate-ubiquinone reductase; inhibition; TTFA;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

It is proved by using the Dixon plot and the Lineweaver-Burk plot that thenoyltrifluoroacetone （TTFA） has two inhibitive sites affecting the reduction of ubiquinone catalyzed by succinate-ubiquinone reductase. The high affinity site （inhibited at the concentration of thenoyltrifluoroacetone less than 20 μmol/L） shows noncompetitive with substrate Q, while the low affinity site （inhibited at the concentration of TTFA over 20 μmol/L） shows competitive. It is suggested that both the reducing steps of Q→QH and QH→QHare inhibited by thenoyltrifluoroacetone.

引用

页码：162 / 168

页数：7

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