In vitro–in vivo studies of the quantitative effect of calcium,multivitamins and milk on single dose ciprofloxacin bioavailability

被引：0

作者：

Baishakhi Dey ^{[1
]}

Prakash Katakam ^{[2
]}

Fathi H.Assaleh ^{[2
]}

Babu Rao Chandu ^{[2
]}

Shanta Kumari Adiki ^{[3
]}

Analava Mitra ^{[1
]}

机构：

[1] School of Medical Science and Technology

[2] Faculty of Pharmacy, University of Zawia

[3] Department of Pharmaceutical Analysis,Nirmala College of Pharmacy

来源：

JournalofPharmaceuticalAnalysis | 2015年 / 5卷 / 06期

关键词：

Ciprofloxacin; Analytical methodology; Bioavailability; Bio-waiver; Dissolution study;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies using UV and HPLC and in vitro dissolution studies(IVIVC) has shown a significant increase in elimination rate of ciprofloxacin co-administered with multivitamins,calcium and milk. Appreciable IVIVC results proved that dissolution studies could serve as an alternative to in vivo bioavailability and also support bio-waivers.

引用

页码：389 / 395

页数：7

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