CD2AP与肾脏

被引:0
|
作者
何伟春
邢昌赢
机构
[1] 南京医科大学第一附属医院肾内科
关键词
肾疾病; 肾小球抗原,CD2;
D O I
暂无
中图分类号
R692 [肾疾病];
学科分类号
摘要
近年来对肾小球疾病发病机制的研究提示 ,足细胞是许多肾小球疾病的主要病变部位 ,有多种足细胞相关的蛋白分子与其功能密切相关 ,CD2相关蛋白 (CD2 associatedprotein ,CD2AP)即为其中之一。本文针对CD2AP的分子特征、在肾脏中的表达、在维持足细胞裂隙孔膜功能和调节细胞骨架中的作用以及与CD2AP缺乏或异常相关的肾脏病变等内容作一综述。
引用
收藏
页码:532 / 535
页数:4
相关论文
共 20 条
  • [1] Lehtonen S,Zhao F,Lehtonen E.CD2-associated protein directly interacts with the actin cytoskeleton. American Journal of Physiology Renal Physiology . 2002
  • [2] Khoshnoodi J,Tryggvason K.Unraveling the molecular make-up of the glomerular podocyte slit diaphragm. Experimental Nephrology . 2001
  • [3] Holthofer H,et al.Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney. American Journal of Pathology . 1999
  • [4] Shih NY,Li J,Cotran R,et al.CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. American Journal of Pathology . 2001
  • [5] Miner JH,Morello R,Andrews KL,et al.Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation. The Journal of Clinical Investigation . 2002
  • [6] Pavenstadt H,Kriz W,Kretzler M.Cell biology of the glomerular podocyte. Physiological Reviews . 2003
  • [7] Rohr C,Prestel J,Heidet L,et al.The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes. The Journal of Clinical Investigation . 2002
  • [8] Kerjaschki D.Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis. The Journal of Clinical Investigation . 2001
  • [9] Lehtonen S,Ora A,Olkkonen VM,et al.In vivo interaction of the adapter protein CD2AP with the type 2 polycystic kidney disease protein, polycystin-2. Journal of Biological Chemistry . 2000
  • [10] Li C,Ruotsalainen V,Tryggvason K,et al.CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere. American Journal of Physiology . 2000