Detection of the Urinary Biomarkers PYD, CTX-Ⅱ, and DPD in Patients with Kashin-Beck Disease in the Qinghai Province of China

被引：2

作者：

ZHAO Zhi Jun ^{[1
]}

PU Guang Lan ^{[1
]}

ZHAN Pei Zhen ^{[1
]}

LI Qiang ^{[1
]}

WU Chun Ning ^{[1
]}

WANG Li Hua ^{[2
]}

机构：

[1] Qinghai Institute for Endemic Disease Prevention and Control

[2] Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University

来源：

BiomedicalandEnvironmentalSciences | 2017年 / 30卷 / 05期

关键词：

CTX; KBD; DPD; Detection of the Urinary Biomarkers PYD; and DPD in Patients with Kashin-Beck Disease in the Qinghai Province of China;

D O I：

暂无

中图分类号：

R599 [地方病学];

学科分类号：

1002 ; 100201 ;

摘要：

Kashin-Beck disease(KBD) is an endemic degenerative osteoarthropathy of uncertain etiology. The aim of our study was to identify changes in C-telopeptide of type Ⅱ collagen(CTX-Ⅱ), pyridinoline(PYD), and deoxypyridinoline(DPD) among KBD patients. 54 KBD patients and 78 healthy controls were included this study. Urinary samples were collected and measured by ELISA. The median quantities of PYD, CTX-Ⅱ, and DPD of KBD patients were 1107.73 ng/μmol.cre, 695.11 ng/μmol.cre, and 1342.34 pml/μmol.cre, while the median quantities of healthy controls were 805.59 ng/μmol.cre, 546.47 ng/μmol.cre, and 718.15 pml/μmol.cre, respectively. The differences between KBD patients and healthy controls were statistically significant(Z = 4.405, 3.653, and 3.724; P < 0.001). The higher levels of PYD, CTX-Ⅱ, and DPD detected in KBD patients indicate that they could be used as biomarkers of KBD.

引用

页码：380 / 383

页数：4

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