Immunotherapy for colorectal cancer

被引：0

作者：

Shigeo Koido ^{[1
,2
,3
]}

Toshifumi Ohkusa ^{[1
]}

Sadamu Homma ^{[2
]}

Yoshihisa Namiki ^{[3
]}

Kazuki Takakura ^{[1
]}

Keisuke Saito ^{[1
]}

Zensho Ito ^{[1
]}

Hiroko Kobayashi ^{[1
]}

Mikio Kajihara ^{[1
]}

Kan Uchiyama ^{[1
]}

Seiji Arihiro ^{[1
]}

Hiroshi Arakawa ^{[4
]}

Masato Okamoto ^{[5
]}

Jianlin Gong ^{[6
]}

Hisao Tajiri ^{[1
]}

机构：

[1] Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine

[2] Department of Oncology, Institute of DNA Medicine, The Jikei University School of Medicine

[3] Institute of Clinical Medicine and Research, The Jikei University School of Medicine

[4] Department of Endoscopy, The Jikei University School of Medicine

[5] Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine

[6] Department of Medicine, Boston University School of Medicine, Boston

来源：

World Journal of Gastroenterology | 2013年 / 19卷 / 46期

关键词：

Colorectal cancer; Cytotoxic T lymphocyte; Dendritic cell; Immunotherapy; vaccine;

D O I：

暂无

中图分类号：

R735.3 [肠肿瘤];

学科分类号：

100214 ;

摘要：

The incidence of colorectal cancer(CRC)is on the rise,and the prognosis for patients with recurrent or metastatic disease is extremely poor.Although chemotherapy and radiation therapy can improve survival rates,it is imperative to integrate alternative strategies such as immunotherapy to improve outcomes for patients with advanced CRC.In this review,we will discuss the effect of immunotherapy for inducing cytotoxic T lymphocytes and the major immunotherapeutic approaches for CRC that are currently in clinical trials,including peptide vaccines,dendritic cell-based cancer vaccines,whole tumor cell vaccines,viral vector-based cancer vaccines,adoptive cell transfer therapy,antibody-based cancer immunotherapy,and cytokine therapy.The possibility of combination therapies will also be discussed along with the challenges presented by tumor escape mechanisms.

引用

页码：8531 / 8542

页数：12

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