Acute myeloid leukemia following a primary mediastinal germ cell tumor

被引：3

作者：

Hong Huimin ^{[1
,2
,3
,4
]}

Su Yan ^{[1
,2
,3
,4
]}

Chen Chenghao ^{[5
]}

He Lejian ^{[6
]}

Zhu Shuai ^{[1
,2
,3
,4
]}

Lin Wei ^{[1
,2
,3
,4
]}

Jin Mei ^{[1
,2
,3
,4
]}

Wang Xisi ^{[1
,2
,3
,4
]}

Zhang Ruidong ^{[1
,2
,3
,4
]}

Zheng Huyong ^{[1
,2
,3
,4
]}

Zeng Qi ^{[5
]}

Ma Xiaoli

机构：

[1] Beijing Key Laboratory of Pediatric Hematology Oncology

[2] National Discipline of Pediatrics, Ministry of Education

[3] MOE Key Laboratory of Major Diseases in Children

[4] Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China

[5] Department of Thoracic Surgery, Beijing Children’s Hospital, Capital Medical University, National Centre for Children’s Health, Beijing, China

[6] Department of Pathology, Beijing Children’s Hospital, Capital Medical University, National Centre for Children’s Health, Beijing, China

来源：

儿科学研究（英文） | 2020年 / 04卷 / 03期

关键词：

Primary mediastinal germ cell tumor; Acute myeloid leukemia; Chemotherapy;

D O I：

暂无

中图分类号：

R733.71 [急性白血病]; R734.5 [纵隔肿瘤];

学科分类号：

100214 ;

摘要：

Introduction: There is a known association between primary mediastinal germ cell tumor (PMGCT) and hematologic malignancy that is not linked to treatment. They are exceptionally rare entities with a low morbidity and a poor prognosis.Case presentation: An 11-year-old boy presented with an anterior mediastinal mass diagnosed as a malignant germ cell tumor on the basis of an excisional biopsy. He was found to have acute myeloid leukemia (AML) two years after the chemotherapy for his germ cell tumor. The clinical course was very aggressive with a survival time of only 1 week after diagnosis of AML associated with PMGCT.Conclusion: AML associated with PMGCT needs to be diagnosed correctly. Relevant examinations should be carried out in patients with PMGCTs during and after chemotherapy, and long-term follow-up is still necessary to reduce the risk of morbidity and mortality.

引用

页码：218 / 221

页数：4

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